Медиаторные и метаболические свойства ГАМК в нервной системе

Родинский А. Г., Демченко Т. В., Романенко Л. А.

ОБЗОРЫ ЛИТЕРАТУРЫ

Научная статья.

В представленном обзоре рассматриваются синаптическая и несинаптическая способность ГАМК на разных стадиях развития нейронной структуры. В основе механизма возбуждающего действия ГАМК эпигенетического фактора контроля важных биологических процессов – ускорение клеточной про-лиферации, миграции нейробластов, созревания дендритов и нейронной дифференцировки, лежат изме-нения клеточной проницаемости как для анионов, так и катионов. Механизмы пластичности включают из-менение возможности выделения ГАМК и постсинаптической реакции на нее.

ГАМК, глутамат, кальций, хлор

• 1. Andersen P. Two different responses of hippocampal pyramidal cells to application of GABA/ P. Andersen //J. Physiol. – 1980. – Vol. 305. – P. 279 -296.
• 2. Asada H. Cleft palate and decreased brain GABA in mice lacking the 67-kDa isoform of glutamic acid decarboxylase / H. Asada, y. Kawamura // Proc. Natl. Acad. Science USA. – 1997. – Vol. 94. – P. 6496-6499.
• 3. Bading H. Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways / H. Bading, D. Ginty, M. Greenberg // Science. – 1993. – Vol. 260, №5105. – P. 181-186.
• 4. Behar T. N. GABA stimulates chemotaxis and chemokinesis of embryonic cortical neurons via calcium-dependent mecha-nisms / T. N. Behar, y. X. Li, H. T. Tran [et al.] // J. Neurosci. – 1996. – Vol. 16, №5. – P. 1808-1818.
• 5. Behar T. N. GABA receptor antagonists modulate postmitotic cell migration in slice cultures of embryonic rat cortex / A. E. Schaffner, C. A. Scott [et al.] // Cereb. Cortex. – 2000. – Vol. 10, №9. – P. 899-909.
• 6. Behr J. Kindling enhances kainate receptor-mediated depression of GABAergic inhibition in rat granule cells / J. Behr, C. Gebhardt, U. Heinemann // Eur. J. Neuroscience. – 2002. – Vol. 16, №5. – P. 861–867.
• 7. Belhage B. Effect of GABA on synaptogenesis and synaptic function/ B. Belhage, G. H. Hansen, L. Elster, [et al.] // Perspectives on Developmental Neurobiology. – 1998. – Vol. 5, №2-3. – P. 235-242.
• 8. Ben Ari y. Excitatory actions of GABA during development: the nature of the nurture / y. Ben Ari // J. Neurosci. – 2002. – Vol. 3, №9. – P. 658–739.
• 9. Ben Ari y. GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations / y. Ben Ari // Physiol. Rev. – 2007. – Vol. 87, №4. – P. 1215–1284.
• 10. Ben-Ari y. Trophic actions of GABA on neuronal development / y. Ben-Ari, A. Represa // Trends Neurosci. – 2005. – Vol. 28, №6. – P. 278-283.
• 11. Bettler B. Molecular structure and physiological functions of GABAB receptors / B. Bettler, K. Kaupmann // Physiol. Rev. – 2004. – Vol. 84, №3. – P. 835–867.
• 12. Boistel J. Membrane permeability change during inhibitory transmitter action in crustacean muscle / J. Boistel // J. Physiol. – 1958. – Vol. 144, №1. – P. 167-191.
• 13. Chen G. Excitatory actions of GABA in rat developing hypothalamic neurones / G. Chen, P. Q. Trombley, A. N. Pol // J. Physiol.– 1996. – Vol. 494. – P. 451–454.
• 14. Cherubini E. GABA: an excitatory transmitter in early postnatal life / E. Cherubini, J. L. Gaiarsa // Trends in Neuroscience. – 1991. – Vol. 14, №12. – P. 515–519.
• 15. Cherubini E. GABA mediated excitation in immature rat CA3 hippocampal neurons / E. Cherubini, C. Rovira, J. L. Gaiarsa // International J. of Developmental Neuroscience. – 1990. – Vol. 8, №4. – P. 481– 490.
• 16. Curtis D. R. The depression of spinal neurones by γ-amino-n-butyric acid and β-alanine / D. R. Curtis, J. W. Phillis // J. Physi-ol. – 1959. – Vol. 1, №1. – P. 185–203.
• 17. Devlin C. L. The pharmacology of GABA and acetylcholine receptors at the echinoderm neuromuscular junction / C. L. Dev-lin // J. Experimental Biology. – 2001. – Vol. 204, №5. – P. 887–896.
• 18. Devlin C. L. Pharmacological identification of acetylcholine receptor subtypes in echinoderm smooth muscle / C. L. Devlin, W. Schlosser, D. T. Belz // Comp. Biochem. Physiol. – 2000. – Vol. 125C. – P. 53–64.
• 19. Elphick M. R. Neuropeptide structure and function in echinoderms / M. R. Elphick // PhD Thesis, Royal Holloway and Bedford New College. – 1991. – 245 р.
• 20. Engel D. Plasticity of rat central inhibitory synapses through GABA metabolism / D. Engel // Journal of Physiology. – 2001. – Vol. 535, №2. – P. 473–482.
• 21. Federico T. F. Enhancement of GABA Release through еndogenous аctivation of axonal gabaa receptors in juvenile cere-bellum / T. F. Federico, A. Marty // J. Neurosci. – 2007. – Vol. 27, №12. – P. 119-123.
• 22. Fiszman M. L. GABA induces proliferation of immature cerebellar granule cells grown / M. L. Fiszman //Brain Res. – 1999. – Vol. 115, №1. – P. 1-8.
• 23. Florey E. An inhibitory and an excitatory factor of mammalian CNS, and their action on a single sensory neuron / E. Florey // Arch. Int. Physiol. – 1954. – Vol. 62, №1. – P. 33–53.
• 24. Florey E. Excitatory actions of GABA and of acetylcholine in sea urchin tube feet / Е. Florey // Comp. Biochem. Physiol. – 1975. – Vol. 51C. – P. 5–12.
• 25. Franklin J. L. Suppression of programmed neuronal death by sustained elevations of cytoplasmic calcium / J. L. Franklin, E. M. Johnson // Trends Neurosci. – 1992. – Vol. 15, №12. – P. 501-508.
• 26. Fritsch B. Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis / B. Fritsch, F. Qashu // Neuroscience. – 2009. – Vol. 163, №1. – P. 415–429.
• 27. Galanopoulou A. S. The epileptic hypothesis: developmentally related arguments based on animal models / A. S. Galanopoulou, S. L. Moshe // Epilepsia, – 2009. – Vol. 7, №50. – P. 37–42.
• 28. Ganguly K. GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition / K. Ganguly, A. F. Schinder, S. T. Wong // Cell. – 2001. – Vol. 105, №4. – P. 521-532.
• 29. Gao X. -B. GABA release from mouse axonal growth cones / X. -B. Gao, A. N. Pol // Journal of Physiology. – 2000. – Vol. 523, №3. – P. 629-637.
• 30. Gascon E. Potentially toxic effects of anaesthetics on the developing central nervous system / E. Gascon, P. Klauser, J. Z. Kiss // European Journal of Anaesthesiology. – 2007. – Vol. 24, №3. – P. 213-224.
• 31. Grattan D. R. GABAergic neuronal activity and mRNA levels for both forms of glutamic acid decarboxylase are reduced in the diagonal band of Broca during the afternoon of proestrus / D. R. Grattan, M. S. Rocca //Brain Research. – 1996. – Vol. 733, №1. – P. 50–55.
• 32. Hensch T. K. Critical period plasticity in local cortical circuits / T. K. Hensch // Nature Reviews Neuroscience. – 2005. – Vol. 6, №11. – P. 877-888 (2005).
• 33. Hensch T. K. Critical period regulation, / T. K. Hensch // Annual Review of Neuroscience. – 2004. – Vol. 27. – P. 549-579.
• 34. Hensch T. K. Local GABA circuit control of experience-dependent plasticity in developing visual cortex / T. K. Hensch, M. Fa-giolini, N. Mataga // Science. – 1998 – Vol. 282, №5393. – P. 1504-1508.
• 35. Hubner C. Disruption of KCC2 reveals an essential role of K-Cl-cotransport already in early synaptic inhibition / C. Hubner, V. Stein // Neuron. – 2001. – Vol. 30, №2. – P. 515–524.
• 36. Jentsch T. J. Molecular structure and physiological function of chloride channels / T. J. Jentsch // Physiol. Rev. – 2002. – Vol. 82, №2. – P. 503-568.
• 37. Jursky F. Structure, function and brain localization of neurotransmitter transporters / F. Jursky, S. Tamura // J. Exp. Biol. – 1994. – Vol. 196. – P. 283–295.
• 38. Kaila K. Influence of GABA-gated bicarbonate conductance on potential, current and intracellular chloride in crayfish muscle fibres / K. Kaila, M. Pasternack, J. Saarikoski // J. Physiol. – 1989. – Vol. 416. – P. 161-181.
• 39. Kaila K. Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate / K. Kaila, J. Voipio // Nature. – 1987. – Vol. 330. – P. 163-165.
• 40. Kobzar G. T. Muscle chemoreceptors in the holothurians / G. T. Kobzar // J. of Evolut. Biochem. and Physiol. – 1984. –Vol. 20, №1. – P. 419–422.
• 41. Krnjevi K. When and why amino acids? / K. Krnjevi // J. Physiol. – 2010. – Vol. 588, №1. – P. 33–44.
• 42. Luhmann H. J. Postnatal maturation of the GABAergic system in rat neocortex / H. J. Luhmann, D. A. Prince // J. Neurophysiol.– 1991. – Vol. 65, №2. – P. 247-263.
• 43. Lujan R. Glutamate and GABA receptor signalling in the developing brain / R. Lujan // Neuroscience. – 2005. – Vol. 130, №3.– P. 567-580.
• 44. McNamara J. O. Cellular and molecular basis of epilepsy / J. O. McNamara // J. Neoroscience. 1994. – Vol. 6, №14. – P. 3413–3425.
• 45. Murphy D. D. Estradiol increases dendritic spine density by reducing GABA neurotransmission in hippocampal neurons / D. D. Murphy // Journal of Neuroscience. 1998. – Vol. 18, №7. – P. 2550–2559.
• 46. Nguyen L. Neurotransmitters as early signals for CNS development / L. Nguyen // Cell Tissue Res. – 2001. – Vol. 305, №2. – P. 187-202.
• 47. Obrietan K. GABA neurotransmission in the hypothalamus: developmental transition from Ca2+ excitatory to inhibitory / K. Obrietan, A. N. Pol // J. Neuroscience. 1995. – Vol. 15, №7. – P. 5065–5077.
• 48. Obrietan K. Growth cone calcium rise evoked by GABA / K. Obrietan, A. N. Pol // J. Comp. Neurol. –1996. – Vol. 365, №2. – P. 167-175.
• 49. Olney J. W. New insights and new issues in neurotoxicology / J. W. Olney // Neurotoxicology. – 2002. -Vol. 23, №6. – P. 659-668.
• 50. Owens D. F. Excitatory GABA responses in embryonic and neonatal cortical slices demonstrated by gramicidin perforated-patch recordings / D. F. Owens // J. Neuroscience. 1996. – Vol. 16, №20. – P. 6414–6423.
• 51. Owens D. F. Developmental neurotransmitters? / D. F. Owens, A. R. Kriegstein // Neuron. – 2002. – Vol. 36, №6. – P. 989-991. 52. Pol A. N. Excitatory actions of GABA after neuronal trauma / A. N. Pol, K. Obrietan // J. Neuroscience. – 1996. – Vol. 16,№13. – P. 4283-4292.
• 53. Reichling D. B. Mechanisms of GABA and glycine depolarization-induced calcium transients in rat dorsal horn neurons / D. B. Reichling, A. Kyrozis, J. Wang // J. Physiol. 1994. – Vol. 476, №3. – P. 411–421.
• 54. Rekling J. C. Synaptic control of motoneuronal excitability / J. C. Rekling, G. D. Funk // Physiological Reviews. – 2000. – Vol. 80, №2. – P. 767-852.
• 55. Rivera C. Two developmental switches in GABAergic signalling / C. Rivera, J. Voipio, K. Kaila // J. Physiol. 2005. – Vol. 562, №1. – P. 27-36.
• 56. Rivera C. The K/Cl co-transporter renders GABA hyperpolarizing during neuronal maturation / C. Rivera // Nature. – 1999. – Vol. 397. – P. 251–255.
• 57. Rohrbough J. Regulation of intracellular Cl- levels by Na+-dependent Cl- cotransport distinguishes depolarizing from hyperpolarizing GABAA receptor responses / J. Rohrbough // J. Neurosci. – 1996. – Vol. 16, №1. – P. 82–91.
• 58. Snead O. C. Gamma-hydroxybutyrate model of generalized absence seizures: further characterization and comparison withother absence models / O. C. Snead // Epilepsia. – 1988. – Vol. 29, №4. – P. 361–364.
• 59. Staley K. J. Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors / K. J. Staley // Science. – 1995. – Vol. 269. – P. 977-981.
• 60. Vaccarino F. Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons / F. Vaccarino // Molec. Brain Research. – 1992. – Vol. 12, №1-3. – P. 233-241.
• 61. Wang J. Developmental loss of GABA- and glycine-induced depolarization and Ca2+ transients in embryonic rat dorsal horn neurons in culture / J. Wang // Eur. J. Neurosci. – 1994. – Vol. 6, №8. – P. 1275–1280.
• 62. Wu W. Early development of glycine and GABA-mediated synapses in spinal cord / W. Wu // J. Neurosci. – 1992. – Vol. 12, №10. – P. 3935–3945.
• 63. yuste R. Control of postsynaptic Ca2+ influx in developing neocortex by excitatory and inhibitory neurotransmitters / R. yuste, L. C. Katz // Neuron. – 1991. – Vol. 6, №3. – P. 333–344.

«Вестник проблем биологии и медицины» Выпуск 2 Том 3 (109), 2014 год, 38-44 страницы, код УДК 612. 741. 743:612. 014. 42