КАНЦЕРОГЕННОСТЬ КАРБЕНДАЗИМА: ИССЛЕДОВАНИЕ В ХРОНИЧЕСКОМ ЭКСПЕРИМЕНТЕ НА КРЫСАХ WISTAR

Лисовская В. С., Недопитанская Н. Н., Решавская Е. В., Баглей Е. А.

ПАТОМОРФОЛОГИЯ

Научная статья.

Изучены канцерогенные свойства карбендазима технического 98 % на крысах Wistar, самцах и самках в условиях хронического 24-месячного эксперимента при введении зондом в желудок в дозах 5, 25 и 75 мг/кг массы тела. Установлено небольшое, но статистически достоверное увеличение частоты опухолей, характерных для спонтанного спектра: у самок – молочной и щитовидной желез, опухолей гипофиза, у самцов – лейдигом без четкой зависимости от дозы: рост частоты опухолей щитовидной железы выявлен в дозе 5 мг/кг, молочной железы – в дозе 5 мг/кг и 25 мг/кг, опухолей гипофиза – в дозе 75 мг/кг, лейдигом – в дозе 25 мг/кг. Увеличение частоты характерных для крыс, преимущественное гормональнозависимых опухолей, при отсутствии сокращения их латентного периода и нечеткой зависимости от дозы свидетельствует о слабом канцерогенном действии карбендазима, вероятнее всего, эпигенетического механизма, что требует дальнейших исследований.

карбендазим, канцерогенез, опухоли, крысы Wistar.

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«Вестник проблем биологии и медицины» Выпуск 1 (155), 2020 год, 321-328 страницы, код УДК 616-006:632.95.024:59.08

10.29254/2077-4214-2020-1-155-321-328