МЕЛАТОНИН КАК ПОТЕНЦИАЛЬНЫЙ КАРДИОПРОТЕКТОР: ЭКСПЕРИМЕНТАЛЬНО-КЛИНИЧЕСКИЙ АНАЛИЗ ЭФФЕКТИВНОСТИ

Зайченко А. В., Горчакова Н. А., Клименко Е. В., Яковлева Н. Ю., Синицина О. С.

ОБЗОРЫ ЛИТЕРАТУРЫ

Научная статья.

В обзорной статье выделено влияние мелатонина, основного гормона эпифиза, на сердечнососудистую систему. Показаны пути его синтеза и механизмы рецепторного метаболитного и других видов активности. Определена его роль в синтезе гормонов, цитопротекторное, антипролиферативное действие. Раскрыть механизмы кардиопротекторного действия мелатонина при ишемии/реперфузии. Указано, что в основе благоприятного влияния мелатонина лежит его антиоксидантная, антирадикальная, вазодилататорная активность. Кроме этого, спектр влияния мелатонина может быть следствием его взаимодействия с симпатической и парасимпатической системами, активностью протеинкиназ, янус-киназы, системой сиртуинов. Мелатонин влияет на сократимость миокарда, понижает частоту сердечных сокращений, тормозит апоптоз, уменьшает размеры инфаркта миокарда. У мелатонина установлено также антигипертензивное действие, которое реализуется благодаря влиянию на вегетативную нервную систему, активность NO-синтазы, содержание нейрональных аминокислот.

мелатонин, ишемия/реперфузия, кардиопротекция, антигипертензивное влияние

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«Вестник проблем биологии и медицины» Выпуск 2 Том 1 (150), 2019 год, 26-35 страницы, код УДК 577:154.365+001.3+616.31

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