ANTIBIOTIC SUSCEPTIBILITY OF OPPORTUNISTIC PATHOGENIC INTESTINAL MICROFLORA FOR DYSBIOSIS IN PATIENTS WITH HEPATITIS B

Sklyar T. V., Lavrentievа K. V., Kremenchuсka P. Е., Lуkholat O. A., Dzhuzha D. O.

MICROBIOLOGY

Scentific article

Microbiological analysis of the intestinal microflora for dysbiosis in patients with hepatitis B (n=35) was conducted. Changes in qualitative and/or quantitative composition of the intestinal microflora were observed in each patient in the experimental group. Among representatives of indigenous microflora, a significant reduction in the number of bifidobacteria was noted in 68%, lactobacilli – in 85% of patients with hepatitis B. Excess of titers of lactose-negative Е. coli strains was observed in 22% сases, and yeast-like fungi Candida – in 35% сases. Opportunistic pathogenic enterobacteria were present in 77% of the clinical samples. The representatives of Klebsiella genus were found in 31% of patients with hepatitis B, Proteus genus – 20%, hemolytic Е. coli strains – in 26% of the patients. In this study of antibiotic susceptibility of opportunistic pathogenic enterobacteria strains isolated from hepatitis B patients with dysbiotic intestinal disorders, it was found that representatives of the genera Klebsiella and Proteus were the most sensitive to ciprofloxacin (73% and 72% of cultures, respectively); lactose-negative E. coli strains – to amikacin and ceftazidime (75% of cultures), cefepime and ciprofloxacin (62% of cultures); hemolytic E.coli strains – to ciprofloxacin and cefepime (78% and 67% of cultures, respectively). The most resistant of isolated strains were oxacillin and doxycycline. Oxacillin inhibited the growth of Klebsiella strains in 9% of cases, lactose-negative E. coli strains – in 25%, hemolytic E. coli strains – in 11% of cases and was ineffective against to Proteus strains. 73% of Klebsiella strains, 86% of Proteus strains, 62% of lactoso-negative E. coli strains and 78% of hemolytic E. coli strains were resistant to doxycycline.

hepatitis В, intestinal microflora, antibiotics

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«Bulletin of problems biology and medicine» Issue 3 (145), 2018 year, 256-259 pages, index UDK 579.61

10.29254/2077-4214-2018-3-145-256-259