STRUCTURAL CHANGES IN THE WALL OF THE ABDOMINAL AORTA UNDER THE INFLUENCE OF IMMOBILIZATION STRESS ON THE BACKGROUND OF PROLONGED SYMPATHICOTONIA IN THE EXPERIMENT

Gavreliuk S. V.

MORPHOLOGY

Scentific article

In the work current questions of studying structural changes in the wall of the abdominal aorta in the experiment with long immobilization stress on the background of sympathicotonia with an increase in the activity of the sympathetic department of the VNS and the normal tone of the parasympathetic department of the VNS are considered. The purpose of this study was to reveal the effect of prolonged sympathicotonia on the structure of the wall of the abdominal aorta in rats in an experiment. The studies were performed on three comparable groups of hundred-day Wistar rats, which for a period of 10 days were exposed to immobilization stress and sympathicotonia. As a method of stress, immobilization stress was chosen, which was modeled by placing the rats in a special plastic pencil box, limiting their movements for four hours at room temperature of the ambient air. As a model of sympathicotonia, sympathicotonia was chosen with an increase in the activity of the sympathetic division of the VNS and the normal tone of the parasympathetic section of the VNS, which was achieved by the administration of α- and β-adrenomimetics of adrenaline tartrate, whose action coincides with the effect of stimulation of sympathetic nerve fibers. The animals were divided into 3 groups of 10 each: I group – control – rats, which were injected subcutaneously with 0.3 ml of a 0.9% solution of NaCl every day, Group II – animals subjected to immobilization stress and Group III – rats, daily subcutaneously injected adrenaline tartrate at a rate of 0.05 mg·kg-1 and subjected to immobilization stress. On the 10th day, the animals were removed from the experiment by decapitation in an anesthetic state (calypsole at the rate of 16 mg·kg-1 of animal weight intraperitoneally). It was found that the support of prolonged immobilization of sympathicotonia with an increase in the activity of the sympathetic division of the VNS and the normal tone of the parasympathetic division of the VNS has a certain angioprotective effect, but does not protect against the development of an inflammatory reaction in adventitia and degenerative changes in the elastic fibers of all layers of the wall of the abdominal aorta.

structure of the vascular wall, abdominal aorta, sympathicotonia

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«Bulletin of problems biology and medicine» Issue 3 (145), 2018 year, 265-269 pages, index UDK 616-092.4:616.136

10.29254/2077-4214-2018-3-145-265-269