THE FEATURES OF LIPID METABOLISM IN PATIENTS WITH CHRONIC PANCREATITIS WITH CONCOMITANT ARTERIAL HYPERTENSION

Filippova A. Yu., Kryvoshei V.V.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Patients with chronic pancreatitis have high frequency of comorbidity, especial with arterial hypertension. The problematic of lipid disorders in patients with chronic pancreatitis and concomitant arterial hypertension is still actual. The aim of this study was to determine the features of lipid metabolism in patients with chronic pancreatitis with concomitant arterial hypertension. Materials and methods. 54 patients aged 45–65 years (median age – 50.7 [45.4; 58.0] years) with chronic pancreatitis in combination with arterial hypertension were examined. Patients were divided into 2 groups: 1st (n=30) – patients with a combined course of chronic pancreatitis and hypertension; 2nd (n=24) – patients with chronic pancreatitis without concomitant hypertension. The content of total cholesterol, triglycerides, high-density cholesterol in serum was determined by standard enzyme-linked immunosorbent assay. Results. Elevated levels of triglycerides, low density cholesterol and total cholesterol were observed in 43 (80 %), 48 (89 %) and 51 (94 %) patients, respectively. Patients of the 1st group had significantly higher levels of triglycerides on 36 %, low density cholesterol cholesterol on 15 %, total cholesterol on 24 %, atherogenic ratio on 18 % and significantly lower high-density cholesterol on 17 %. The duration of chronic pancreatitis was positively correlated with the level of triglycerides, low-density cholesterol – r=0.40; p=0.0013; r=0.39; =0.0034, respectively. Men had a significantly higher level of cholesterol, high-density cholesterol, triglycerides, atherogenic ratio compared to women – by 17.2 %, 15.1 %, 32.8 % and 24.8 %, respectively. Conclusions. Patients with a comorbid course of chronic pancreatitis with arterial hypertension had statistically more significant changes lipid metabolism disturbance. The presence of arterial hypertension may predict decreasing of highdensity cholesterol in patients with chronic pancreatitis.

blood lipid profile, high density lipoproteins, chronic pancreatitis, arterial hypertension.

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«Bulletin of problems biology and medicine» Issue 2 Part 1 (164), 2022 year, 260-263 pages, index UDK 616.35–002.2:616.12–008.330–07

10.29254/2077-4214-2022-2-1-164-260-263