ASSOCIATION OF THE ADIPONECTIN GENE POLYMORPHISM WITH THE SEVERITY OF METABOLIC DISORDERS IN ARTERIAL HYPERTENSION WITH DIFFERENT BODY MASS

Psarova V. G., Kochuieva M. N.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

The aim of the study was to investigate the association of the G276T marker polymorphism of the adiponectin gene with the severity of metabolic disorders in arterial hypertension (AH) with different body mass. We examined 300 patients with AH from 45 to 55 years old who gave informed written consent to participate in the study and met the inclusion criteria. Group 1 consisted of 200 patients with AH and obesity I–II classes, group 2 – 50 patients with AH and normal body weight, group 3 – 50 patients with AH and overweight. The control group consisted of 30 practically healthy individuals, in whom AH and obesity were excluded on the basis of clinical and instrumental examination data. As a result of the study, it was established THAT the T allele of the polymorphic marker G276T of the adiponectin gene is associated with the development of AH and concomitant obesity. In patients with AH, the influence of the G276T polymorphism of the adiponectin gene differs depending on the body weight. In patients with comorbidityof AH and obesity, in the presence of G/T- and T/T-genotypes, metabolic disorders are more pronounced than as compared to G/G-genotype: a significantly higher body mass index (BMI), higher triglyceride levels, more pronounced insulin resistance (IR) and adipokine imbalance. The presence of the G/T-genotype of the adiponectin gene in patients with AH and normal body mass is associated with higher BMI, and in patients with AH and overweight – in addition with more severe IR.

arterial hypertension, obesity, adiponectin gene polymorphism, insulin resistance, metabolic parameters.

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«Bulletin of problems biology and medicine» Issue 2 Part 2 (151), 2019 year, 156-160 pages, index UDK 616.12-008.331.1:613.25:616.43-008.6:575.22

10.29254/2077-4214-2019-2-2-151-156-160