MORPHOMETRIC ANALYSIS OF THE AORTIC ROOT IN WOMEN WITH AORTIC STENOSIS

Pidvalna U. Yе.

MORPHOLOGY

Scentific article

Introduction. Modern endovascular methods of severe aortic stenosis correction involve detailed mophrometric analysis of the aortic root and adjacent structures. Objectives. To conduct morphometric analysis of the aortic root by measuring the height of the right, left, and posterior aortic sinuses as well as the right and left coronary arteries ostia in women with severe aortic stenosis while performing contrast-enhanced aortic computed tomography. Based on the obtained results, to establish a model for predicting the size of the studied structures. Materials and methods. The object of study is the aortic root and the coronary arteries ostia in female patients with severe aortic stenosis. The method of research is computed tomography of the aorta with contrast enhancement, mathematical and statistical calculations. Results. The study included computed tomography images of 26 patients with severe aortic stenosis, with a mean age of 64.92±14.07 years. Morphometric analysis data: the height of the posterior aortic sinus 19.42±2.68 mm, the height of the left aortic sinus 18.64±2.39 mm, the height of the right aortic sinus 17.59±2.41 mm. The height of the branching of the lower and upper edges of the right coronary artery ostium 10.88±3.45 mm and 14.19±2.58 mm, the left coronary artery ostium 11.20±2.27 mm and 14.72±2.63 mm, respectively. According to the results of the linear correlation analysis, a strong direct relationship is observed between the height of the posterior aortic sinus and the height of the left aortic sinus (r= +0.74, p=0.004); a medium-strength relationship is found with the height of the left coronary artery ostium (r= +0.63, p=0.02). A strong direct correlation is proven between the height of the left aortic sinus and the height of the left coronary artery ostium (r= +0.83, p=0.0005). Similarly, a strong direct correlation is detected between the height of the right aortic sinus and the height of the right coronary artery ostium (r= +0.84, p=0.0004). Multifactor regression analysis revealed a significant strong direct regression effect of age, height, weight, and body mass index on the height of the right aortic sinus. In particular, the direct effect of age, height, and body mass index as well as the inverse effect of weight on the level of the height of the right aortic sinus have been documented. The linear equations of the constructed logistic model were tested for efficiency after calculating the predicted values of the right aortic sinus height for two studied patients who had different anthropometric and age parameters.Conclusions. Females with severe aortic stenosis do not have proven paired correlations of age and anthropometric parameters with the morphometric parameters (the aortic sinus height and the height of the coronary artery branching) when analyzing the aortic root based on the CT images. There is a direct relationship between the height of the aortic sinuses and the height of the coronary arteries ostia.

aorta, morphometry, aortic sinuses, coronary arteries.

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«Bulletin of problems biology and medicine» Issue 2 Part 2 (165), 2022 year, 136-146 pages, index UDK 611.132:616.132-007.271-055.2]-07

10.29254/2077-4214-2022-2-2-165-136-146