SCLEROSING VILLAS OF THE VULVA AS A CONSEQUENCE OF DISEASES OF THE GASTROINTESTINAL TRACT IN WOMEN OF REPRODUCTIVE AGE

Dunaevska V. V., Manzhalii E. H.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Introduction. Lichen sclerosus (LS) is a chronic inflammatory skin disease that manifests itself in the form of painful, itchy atrophic ivory color spots, most often in the genital area in girls in the premenarchal period or in postmenopausal women. Prolonged illness can lead to scarring, genital distortion and an increased risk of developing squamous cell carcinoma in the affected areas. Genetic, immunological and hormonal factors are involved in the pathogenesis of LS, but the exact etiology of the disease still remains unclear. The aim of this study was to determine the clinical course of intestinal dysbiosis in women of reproductive age diagnosed with vulval lichen sclerosus (VLS). Materials and methods. 77 women of reproductive age with typical clinical signs of VLS were involved in the study, among whom were patients (78%) with a history of dysbiosis and patients (22%) without dysbiosis. Information about all patients was collected through direct interviews, clinical examinations and medical histories. The common symptoms such as presence or absence of anogenital itching, soreness, pain or burning, dryness, dyspareunia, urinary symptoms, perianal and/or intestinal symptoms and bleeding have been reported. Results. The results of bacteriological investigation showed the imbalance of the normal gut microbiota, low levels of bifidobacteria and lactobacilli in 70.3% and 72.3% patients respectively and the presence of pathogenic bacteria in 72.3% of patients with dysbiosis compared with the control group of patients, the content of gut microbiota in 76.47-94.11% of which was normal. However, in the history of patients of the control group thyroid disease, including autoimmune thyroiditis, were diagnosed in 14 (82.3%) patients that may be one of the causes of VLS. Conclusions. Consequently, the analysis of the obtained research results show that dysbiosis is involved in the genesis of VLS, and in addition, further research is needed to assess the causal changes in the microbiota due to the underlying disease and the selection of alternative therapies.

lichen sclerosus, vulva, dysbiosis, gastrointestinal tract

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«Bulletin of problems biology and medicine» Issue 4 (162), 2021 year, 120-123 pages, index UDK 618.16:616-093/-098

10.29254/2077-4214-2021-4-162-120-123