Matsko N. V., Bondarenko Y. I.


About the author:

Matsko N. V., Bondarenko Y. I.



Type of article:

Scentific article


Development of periodontal diseases which is associated with peptic and duodenal ulcers is charac-terized by the concealed type of development, causing difficulty in diagnosis and assignment of prompt treatment. Their main clinical manifestations in the oral cavity are leveled by symptomatology of somatic disease. In addition, the drug therapy with the inclusion of antibiotics which is directed to the treatment of peptic ulcer disease, sup-presses the immune system. This leads to disruption of the ratio between the normal and pathogenic-aggressive oral microflora, leading to a weakness of local periodontal protective factors causing aggravation of inflammatory and degenerative processes in periodontium. Important role in the formation of a complete immune response is assigned to specific and nonspecific protection factor of general and local nature, which functional capacity deter-mines the character of periodontal disease and positively affects their recovery. The aim of the study was figuring out peculiarities of disturbances nonspecific and specific protective factors in the mechanisms of damage periodontal tissues in patients with gastroduodenal ulcer. A study in 39 patients with clinically diagnosed gastric and duodenal ulcers who were hospitalized in the gastroenterology departments of Ter-nopil city hospitals and the control group of 15 persons with clinically healthy periodontium without severe somatic pathology was done. The material of immunological studies was deoxygenated blood and unstimulated mixed saliva (oral fluid), the collection of which was performed in the morning on an empty stomach. Analysis of immunological research in biological fluids of patients with periodontal pathology and gastroduodenal ulcers has been provided. Research of blood serum and oral fluid immunoglobulins confirms significant changes in the examined persons compared with the control group It was established that the development of inflammation in periodontal tissues is characterized by increased levels of Ig A, Ig G, Ig M in serum and increased activity of lysozyme, levels of Ig A, Ig G in oral fluid. Also inflammatory and destructive changes in the periodontium are accompanied by decreased activity of lysozyme and increased levels of Ig A in oral fluid. Prolonged maintaining of increased levels of serum and secretory Ig A caused by influence of gastric and duodenal ulcers, does not lead to reduction of periodontal pathogenic fac-tors, but rather contributes to chronic inflammatory and destructive effects in periodontal tissues. The inflammatory response in periodontal tissue associated with gastric and duodenal ulcers is accompanied by activation of protec-tive mechanisms of the oral cavity from the humoral immune system and non-specific protection mechanisms. The progression of periodontal disease and the transition to generalized form of periodontitis are associated with the depletion of immune mechanisms and decreased levels of lysozyme in biological fluids. The presence of somatic pathology contributes to exacerbation inflammatory and degenerative processes in periodontal tissues, leads to their aggravation and chronicity.


periodontal disease, gastric and duodenal ulcers, immunoglobulins, lysozyme


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Publication of the article:

«Bulletin of problems biology and medicine» Issue 2 part 1 (107), 2014 year, 248-250 pages, index UDK 616. 314. 17-02:616. 33/. 342-002. 44]-092. 19