Vydoynyk O. Ya.

The Parameters of Homeostasis of the Oral Cavity in Children with Dental Disease on the Background of Bronchial Asthma

About the author:

Vydoynyk O. Ya.



Type of article:

Scentific article


The problem of dental caries and periodontal inflammatory disease a background of somatic morbid- ity in children remains relevant, since the trend of increasing prevalence and intensity of these diseases is deter- mined in persons of childhood in recent years. Significant for the decision of this question there is a transcript of mechanisms where mineralization of enamel and processes of inflammatory diseases of fabrics of parodont, which causes an important role in the study of biochemical changes in the oral fluid, which may be clinical and morphologi- cal manifestations of the pathological process in the oral cavity. Interpretation of biochemical parameters of oral liquid can serve as an objective criterion that characterizes the efficiency of various means of prevention of dental caries and periodontal diseases in children on the background of concomitant somatic diseases. The aim of the study was to investigate some biochemical indicators of oral liquid children 7-15 years with dental disease on the background of bronchial asthma. Materials and research methods. 195 children, of whom 26 persons were dental healthy (control group); 49 chil- dren in the presence of dental disease without chronic somatic pathology was a comparative group; 120 people formed a core group who have been diagnosed caries and inflammatory diseases of fabrics of parodont at the background of bronchial asthma were attended in the experiment. Biochemical parameters were found in the supernatant fraction of mixed saliva that received by centrifugation at 3000 last rev / min. for 10 minutes determined the content of malondialdehyde (MDA), and determined the content of malondialdehyde (MDA), the activity of catalase (KA) and superoxide dismutase (SOD) activity of glutathione peroxidase, content apartmanima, total proteolytic activity, the number of leukocytes in oral liquid, speed salivation, pH oral liquid. The results were processed statistically with using software packages for statistical processing of Microsoft Excel for Windows 4. 0 and Statistica 6. 0. Results of research and their discussion. Comparative analysis of the functional activity of salivary glands, indica- tors of prooxidant-antioxidant system, proteolytic activity in oral liquid of children with dental diseases on the back- ground of bronchial asthma has allowed to reveal the basic mechanisms of acute pathologic processes in the oral cavity of examined children. Detailed features of oral liquid homeostasis in children with dental disease on the background of BA were analyzed separate indicators in dental caries and diseases of periodontal tissues in comparison with children with dental men- tioned diseases whose history were no somatic disease. It was investigated increase of speed salivation, MDA content while reducing pH of saliva in children with dental caries on the background of bronchial asthma relation to these children a comparative group. The imbalance in the system of antioxidant protection in children of the main group with dental caries was characterized by the decrease in oral liquid analtube enzymes in relation to these children with dental caries in comparative group. It has been showed an increase in the number of leukocytes in the oral swabs, total proteolytic activity and aspartame content in the chil- dren of main group with dental caries. It was investigated speed increase in salivation and level of aspartame content in children with parodont diseases on the background of bronchial asthma in relation to these children with diseases of parodont without somatic dis- eases. At the same time, noted a significant decrease in the pH of the saliva and levels of enzymes system APS. Conclusions. Thus, research shown that children with dental diseases on background of bronchial asthma have been an increasing function of the salivary glands (speed increase salivation), intensification of the LPO with the deple- tion of antioxidant system, raising the level of the total proteolytic activity, the intensity of factors of local immunity cellular level, leading to significant deterioration in the clinical course of dental caries and periodontal diseases in this group of patients.


dental caries, inflammatory disease of parodont, children, bronchial asthma


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Publication of the article:

«Bulletin of problems biology and medicine» Issue 3 part 1 (110), 2014 year, 47-50 pages, index UDK 616. 314. 18–002. 4–031. 81–322