Onul N. M.

Problem of Male and Female Infertility in Conditions of Technogenic Environmental Pollution

About the author:

Onul N. M.



Type of article:

Scentific article


Introduction. Preservation and strengthening of reproductive health of Ukrainian population, its fertility is one of the leading problems of medical and social nature, that potentiated large-scale anthropogenic pollution. The aim of the research – to analyze the frequency and prevalence of infertility among the population of the industrial region, to determine its sex, spatio-temporal peculiarities and environmental determination degree. Materials and methods. Analysis of the frequency and prevalence of infertility conducted among the urban population of fertile age for both genders in Dnipropetrovsk region at the period 2006-2010 years according to the International Classification of Diseases (ICD-10). The study was conducted in industrial cities – Dnepropetrovsk and Krivoy Rog and control, relatively “pure” Novomoskovsk. The influence of toxic substances at the level of infertility was performed using the methods of correlation analysis and risk assessments. Results. The results of epidemiological researches indicate higher rates of male and female infertility in industrial cities – in 2,1-5,5 times higher compared to control city and in 1,1-3,9 times higher than the average statistical level in Ukraine and the results of research in some other regions of the country what appropriately refers Dnipropetrovsk region in rank of areas with consistently high levels of dysfunction of the reproductive system. That, together with the results of correlation analysis and risk assessment indicates a significant specific weight of environmental factors in the formation and development of this pathology, confirming the position of ecological reproductology about the negative effects technogenic contamination of the environment on human generative system, in particular, in terms of fertility. It is revealed, that the industrial city – Dnipropetrovsk characterized by diametrically opposite changes in the frequency of male and female infertility. For the period of 2006-2010 years, there has been a significant decrease in frequency of male infertility in 1. 2 times, compared with the increase in 1. 2 times this pathology among women. It was found an equal number of interactions between all investigated environmental xenobiotics and indicators of male and female infertility. It is revealed, that the highest share among heavy metals, that negatively affect the performance of male and female fertility has lead – 50 % and 45. 5 % respectively of all identified relationships, confirming globality and the dangers its dissemination in the industrial regions. The relative risk of infertility in the population, that exposed to increased anthropogenic burden conditions for a comprehensive income of xenobiotics, especially lead to the body is 47. 12 ± 1. 42 for males and 5. 96 ± 0. 29 for women, indicating a greater environmental conditionality this nosology among the male population.


frequency, the prevalence of infertility, an industrial region, the impact, the environmental determinacy


  • Авраменко Н. В. Аспекты репродуктивного здоровья населения Украины / Н. В. Авраменко, Д. Е. Барковский // Запо- рожский медицинский журнал. – 2010. – Т. 12, № 3. – С. 71-73.
  • Білецька Е. М. Важкі метали навколишнього середовища як фактор гіпофертильності чоловіків (огляд) / Е. М. Білецька, Н. М. Онул, Т. А. Головкова // Вестник гигиены и эпидемиологии. – 2011. – Т. 15, № 1. – С. 9-13.
  • Довідник з питань репродуктивного здоров’я / за заг. ред. Н. Г. Гойди. – К.: Вид-во Раєвського, 2004. – 128 с.
  • Медико-демографічна ситуація та організація медичної допомоги населенню у 2010 році: підсумки діяльності системи охорони здоров’я та реалізації Програми економічних реформ на 2010-2014 роки «Заможне суспільство, конкуренто- спроможна економіка, ефективна держава». – К.: МОЗ України, 2011. – 104 с.
  • Основні показники діяльності акушерсько-гінекологічної служби і стану здоров’я жіночого населення України: 1990- 2002 роки. – К.: МОЗ України, Центр медичної статистики, 2003.
  • Тяжелые металлы внешней среды и их влияние на репродуктивную функцию женщин / [Сердюк А. М, Белицкая Э. Н., Паранько Н. М., Шматков Г. Г.]. – Д.: АРТ-ПРЕСС, 2004. – 148 с.
  • Щорічна доповідь про стан здоров’я населення України та санітарно-епідемічну ситуацію. 2008 рік. – К., 2009. – 360 с.

Publication of the article:

«Bulletin of problems biology and medicine» Issue 3 part 3 (112), 2014 year, 51-54 pages, index UDK 618. 177:616. 697:504. 054