MODERN REPRESENTATIONS ABOUT PROCESSES OF RE-MODELING OF STRUCTURAL COMPONENTS OF THE CEREBELL UNDER CONDITIONS OF ACTION OF THE COMPLEX OF CHEMICALS

Bilash S. M., Pronina O. M., Kononov B. S.

LITERATURE REVIEWS

Scentific article

This paper presents a review of the literature with the aim of revealing information about the structure of the cerebellum of rats and the effect of a complex of chemicals on it. Currently, the use of products in which a large number of food additives is very common, but unlike some European countries, their concentration is greater in our country. There are also substances that are banned in these countries. Some sources indicate the effect of food additives on various organs and systems of the human body, but only the effect of each individually is described. It has been proven that adults animals and people are resistant to high doses of monosodium glutamate. The rapid absorption of sodium glutamate prevents the accumulation of free glutamic acid in blood plasma and does not lead to the risk of damage to sensitive brain tissues. Certain groups of people are especially sensitive to monosodium glutamate; they report symptoms such as sweating, abdominal and chest pain, headache, nausea, tachycardia, and weakness, but the mechanism of its action has not been clarified yet. Long-term daily use of sodium glutamate in rats, even at safe doses, leads to morphological changes in the colon wall in the form of focal inflammatory changes of the mucous membrane, circulatory disorders in the intestinal wall, the emergence of erosive and ulcerative lesions, as well as changes in the palate, in terms of potentiation of carcinogenesis in the mucous membrane of the colon. Concerning the potential disturbance of the neuroendocrine axis, the FASEB team of experts paid particular attention to the possibility of the potential for dietary glutamate to adversely affect the structure and function of brain regions not protected by the blood-brain barrier. However, the introduction of monosodium glutamate in the diet of newborn mice and rats over time causes them to be obese and diabetes. Therefore, monosodium glutamate is not recommended to add foods intended for baby food. Additives ponceau 4R and sunset yellow are banned in some countries, because there may be an adverse effect on human health. They can cause various allergic reactions and contribute to the development of pathological symptoms. Amyloid protein fibrilogenesis is known to be the main cause of many diseases, such as Parkinson’s disease, Alzheimer’s and Huntington’s disease, amyloid polyneuropathy, type II diabetes, etc. These additives in turn inhibit the formation of amyloid fibrils, which is possible to relate the risk of developing these diseases. The UK government food standards agency has also found that nutritional supplements can cause hyperactivity in children. So if there is information about the existence of the problem and the lack of sufficient knowledge about the effect of a complex of chemicals on the rat cerebellum and its structure, this study is relevant.

cerebellum, rats, nutritional supplements, chemicals, sodium glutamate, ponceau 4R, sunset yellow

1. Zinchenko MO, Holubchykov MV, Mishchenko TS. Stan nevrolohichnoyi sluzhby v Ukrayini v 2015 hodu. Kharkiv: 2015. s. 1-9. [in Ukrainian].
2. Moskalenko VF, Hulʹchiy OP, Hruzyeva TS, Lekhan VM, Pershahen Y, Khernandes R, ta in. Hromadsʹke zdorov’ya: pidruchnyk dlya stud. vyshchykh med. navch. zakladiv. Vinnytsya: Nova Knyha. 2013;3:195-6. [in Ukrainian].
3. Humenyuk HD, Kiyko VV. Kontrolyuvannya yakosti ta bezpechnosti kharchovykh produktiv u zarubizhnikh stranakh. Standartyzatsiya, sertyfikatsiya, yakistʹ. 2019;4(116):24-30. [in Ukrainian].
4. Voloshyn PV, Maruta NO. Оsnovni napryamky naukova rozrobok v nevrolohiyi, psikhiatriyi ta narkolohiyi v ukrayini. Ukrayinsʹkyy visnyk psykhonevrolohiyi. 2017;25.1:10-2. [in Ukrainian].
5. Gayvoronskiy IV. Normal’naya anatomiya cheloveka: uchebnik dlya med. Vuzov. Pererab. i dop. SPb: SpetsLit. 2013;2.8:51. [in Russian].
6. Kurepina NN, Ozhigova AP, Nikitina AA. Anatomiya cheloveka: ucheb. dlya studentov vuzov. M.: Gumanitariy. izd. tsentr VLADOS; 2014. s. 186-92. [in Russian].
7. Tsymbalyuk V, Medvedyev V, Senchyk Yu. Ce.re.bellum, abo mozochok [monohrafiya]. Vinnytsya: Nova knyha; 2013. s. 14-20. [in Ukrainian].
8. Bukanovoy YV. Bol’shoy atlas anatomii cheloveka per. s angl. Moskva: Astrel’, Kladez’; 2013. s. 106-13. [in Russian].
9. Koveshnikova VH. Anatomiya lyudyny. Luhansʹk. 2008;3:46-9. [in Ukrainian].
10. Holovatsʹkyy AS, Cherkasov VH, Sapin MR, Parakhin AI, Kovalʹchuk OI. Anatomiya lyudyny: pidruchnyk. Vinnytsya: Nova Knyha. 2015;2.3:252- 3. [in Ukrainian].
11. Bilich GL, Zigalova YY. Anatomiya cheloveka: russko-latinskiy atlas. Moskva: Izdatel’stvo «E». 2016;2:543-5. [in Russian].
12. Nozdrachev AD, Polyakov EL. Anatomiya krysy (laboratornyye zhivotnyye). SPb.: Izdatel’stvo «Lan’»; 2001. s. 290-4. [in Russian].
13. Bekesevich AM. Morfolohichni osoblyvosti struktury koru mozochka shchura v normi ta za umov trivaloho vplivu opioyidu. Zaporizʹkyy medychnyy zhurnal. 2015;3:82-5. [in Ukrainian].
14. Fomina KA. Anatomo-morfofunktsionalʹna kharakterystyka holovnoho mozku shchuriv riznoho viku pislya inhalyatsiynoho vplyvu epikhlorhidrina. Ukrayinsʹkyy zhurnal klinichnoyi ta laboratornoyi medytsyny. 2012;7.2:153-6. [in Ukrainian].
15. Pronina OM, Koptev MM, Bilash SM, Yeroshenko GA. Response of hemomicrocirculatory bed of internal organs on various external factors exposure based on the morphological research data. SMB. 2018;1(63):153-7. DOI: 10.26.724/2079-8334-2018-1-63-153-157
16. Bilash SM. Reaktsiya Sudin hemomikrotsyrkulyatornoho rusla stinki fundalʹnoho viddilu shlunku na Hostra eksperymentalʹnyy hastryt, vvedennya preparatu «Plateks-platsentarnoho» ta pry yikh sumisniy Diyi. Visnyk problem biolohiyi y medytsyny. 2012;4.1(96):188-92. [in Ukrainian].
17. Bekesevich AM. Osoblyvosti strukturnoyi orhanyzatsyy lanok hemomikrotsyrkulyatornoho rusla koru mozochka shchura za umov 2- ta 4 Tyzhnevyy Vvedennya opioyidu. Klinichna anatomiya ta operatyvna khirurhiya. 2016;15.1:24-7. [in Ukrainian].
18. Eyzler A. Yevropeyskoye issledovaniye: BADy, vitaminy, GMO, bioprodukty. Kak sdelat’ pravil’nyy shag k zdorovomu dolgoletiyu. Izdatel’stvo Eksmo; 2016. s. 335-6. [in Russian].
19. Torshyn IY, Hromova OA. Ekspertnyy analiz danykh v molekulyarnoyi farmakolohiyi. M.: MTSNMO; 2012. s. 114. [in Russian].
20. Perepada OM. Syndrom defitsitu uvahy ta hiperaktivnosti yak medyko-psykholohichna problema. Problemy suchasnoyi psykholohiyi. 2010;10:591-2. [in Ukrainian].
21. Belkov SS. Veshchestvo s umami. Populyarnaya mekhanika. 2012;4:15-20. [in Russian].
22. Moroz VM, Yoltukhivsʹkiy MV. Fiziolohiya. Korotkyy kurs: navch. posibnyk dlya medychno y farmatsevtychnykh VNZ. Vinnytsya: Nova Knyha; 2015. s. 342-3. [in Ukrainian].
23. Donchenko LV, Sokil NV, Shcherbakova EV, Krasnoselova EA. Pishchevaya khimiya. Dobavki: ucheb. posobiye dlya vuzov. ispr. i dop. M.: Izdatel’stvo Yurayt. 2018;2:9-10. [in Russian].
24. Baranovskiy AY. Diyetologiya. SPb.: Piter 2017;5:423-4. [in Russian].
25. Kalapanda M. Appaiah. Monosodium Glutamate in Foods and its Biological Effects. In Ensuring Global Food Safety. 2010;13:217-8.
26. Butnariu M, Sarac I. What is sodium glutamate and what effects it has on health. Journal of Applied Biotechnology and Bioengineering. 2019;6(5):223-6.
27. Smolyar VI. Toksychni efekt kharchovykh dobavok. Problemy yspolʹzovanye kharchovykh dobavok v Ukrayini. Tezy dopovidey Mizhnarodnoyi naukovo-tekhnichnoyi konferentsyy. NUKHT. 2005. s. 53. [in Ukrainian].
28. Kolenchenko OO, Falayeyeva TM, Berehova TV, Kuryk OH. Strukturno-funktsionalʹni zminy v stintsi tovstoho kyshechnyka za umov vvedennya hlutamatu natriyu. Ukrayinsʹkyy zhurnal medytsyny, biolohiyi ta sportu. 2017;5:39-42. [in Ukrainian].
29. Zhou Y, Danbolt NC. Glutamate as a neurotransmitter in the healthy brain. Journal of Neural Transmission. 2014 Aug;121(8):799-817.
30.  Walker R, Lupien JR. The Safety Evaluation of Monosodium Glutamate. The Journal of Nutrition. 2000 Apr;130(4):1049-52.
31. Leulescu M, Lacobescu G, Bojan M, Rotaru P. Ponceau 4R azoic red dye. Journal of Thermal Analysis and Calorimetry. 2019;138(11):2091-101.
32. Kobun Rovina, Pillai Perumal Prabakaran, Shafiquzzaman Siddiquee, Sharifudin Md Shaarani. Methods for the analysis of Sunset Yellow FCF (E110) in food and beverage products. TrAC Trends in Analytical Chemistry. 2016;85:47-56.
33. Sarafanova LA. Pishchevyye dobavki. Eniklopediya. Sankt Peterburg. 2004;2:257-9. [in Russian].
34. Sabera Millan, Lakkoji Satish, Krishnendu Bera, Harekrushna Sahoo. Binding and inhibitory effect of the food colorants Sunset Yellow and Ponceau 4R on amyloid fibrillation of lysozyme. New Journal of Chemistry. 2019;9:3956-68.
35. Stupin FP, Tatkov OV. Izbrannyye voprosy ekologii. Informatsionno-metodicheskiy sbornik. 2017. 110 s. [in Russian].

«Bulletin of problems biology and medicine» Issue 1 (155), 2020 year, 20-25 pages, index UDK 611.817.1:615.917

10.29254/2077-4214-2020-1-155-20-25