MARKERS OF APPEARANCE OF RETINAL VEIN OCCLUSION AFTER CARDIOSURGICAL INTERVENTIONS USING ARTIFICIAL BLOOD CIRCULATION
About the author:
Rykov S. O., Venediktova O. A.
CLINICAL AND EXPERIMENTAL MEDICINE
Type of article:
The main reasons for the development of retinal vein occlusion after cardiac surgery using artificial blood circulation (AC) is acute inflammation that occurs during and immediately after surgery and endothelial dysfunction. Aim of this study: to establish a relationship between markers of inflammation (IL-6 and IL-8) and endothelial dysfunction (VE-C) as possible factors for the occurrence of retinal vein occlusion after cardiac surgery using AC. Object and methods. The study included data from examination of 137 eyes (126 patients, the main group) with retinal vein occlusion after surgery with AC. The comparison group included examination data of 86 eyes (43 patients), which during the entire observation period (180 days) did not have retinal vascular occlusion. The control group consisted of 10 eyes (5 patients) without occlusion, which were examined before surgery. Patients were examined by an ophthalmologist 2, 7, 30, 60, 90 and 180 days after cardiac surgery. The content of IL-6, IL-8 and VE-C in blood serum was determined by enzyme immunoassay (Bender Medsystems, Austria). Statistical data processing was performed using the Statistica 10 software (StatSoft, Inc., USA). Results. Cardiac surgery using AC contributed to an increase in blood levels of IL-6 and VE-C in 1.1-1.2 times (p <0.05) compared with the level before the operation. In the presence of retinal vein occlusion, the content of these markers was increased more significantly (1.7–2.6 times; p <0.001). The content of IL-8 did not differ significantly from the control in both groups. In terms of the occurrence of occlusion, the content of IL-6 was constantly increased, and without occlusion, only on the 2nd and 7th day. The content of IL-8 was higher when occlusion occurred up to 30 days, and the content of VE-C significantly (2.0-2.2 times; p <0.001) exceeded the control in the later stages (after 30 days). For the occurrence of occlusion at all periods, IL-6 was important, from 2 to 60 days – IL-8, and from 30 days – VE-C. At 30 and 60 days, all markers were significant, which reflects the primary damaging effect of inflammation and endothelial dysfunction on these dates. Conclusions. In the postoperative period after cardiac surgery with AC, retinal vein occlusion has a different pathogenesis – acute inflammation in the early stages and secondary endothelial dysfunction – in the late ones, which necessitates various diagnostic and therapeutic approaches to the management of such patients.
retinal vein occlusion, artificial blood circulation (cardiopulmonary bypass), IL-6, IL-8, VE-cadherin.
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Publication of the article:
«Bulletin of problems biology and medicine» Issue 1 (155), 2020 year, 193-199 pages, index UDK 616.145.154-065.6+617.7-07-06:[616.126.32:616.132:616.132.2]