ANALYSIS OF SERUM INTERLEUKIN 6 AND INTERLEUKIN 10 INFORMATIVENESS IN DETECTING OF SHORTTERM PROGNOSIS IN PATIENTS WITH ACUTE PERIOD OF SPONTANEOUS SUPRATENTORIAL INTRACEREBRAL HEMORRHAGE

Kozyolkin O. A., Kuznietsov A. A.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Abstract. Aim of the study was to evaluate informativeness of serum interleukin 6 and interleukin 10 in detecting of short-term prognosis in patients in acute period of spontaneous supratentorial intracerebral hemorrhage on the ground of conservative treatment. Materials and methods. Prospective cohort comparative study was done that included 104 patients with SSICH. Diagnosis was made by using clinical neurovisualization investigation. Serum interleukin 6 and interleukin 10 concentrations were measured with immunoassay analysis. Unfavorable variants of spontaneous supratentorial intracerebral hemorrhage course and outcome on the ground of conservative treatment were considered as end points. Statistical data processing was performed with Statistica 13.0 and MedCalc (version 18.2.1) using logistic regression analysis, ROC-analysis and correlation analysis. Results. Patients with unfavorable spontaneous supratentorial intracerebral hemorrhage course and outcome on the 1st day of admission were characterized with higher serum levels of interleukin 6 and interleukin 10 that correlated with brain injury severity. High sensitive multipredictive models that integrate prognostic value of serum interleukin 6 level with informativeness of clinical neurovisualization parameters during 1st day of admission are elaborated on the ground of logistic regressive analysis. These models allow to predict unfavorable variants of spontaneous supratentorial intracerebral hemorrhage acute period outcome on the ground of conservative treatment with accuracy >85,0% (AUC>0,90). Conclusions. Initial level of interleukin 6 in serum of patients with spontaneous supratentorial intracerebral hemorrhage in comparison with interleukin 10 are more informative indicators for short-term disease prognosis on the ground of conservative treatment.

intracerebral hemorrhage, interleukin 6, interleukin 10, prognosis.

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«Bulletin of problems biology and medicine» Issue 1 (159), 2021 year, 80-87 pages, index UDK 616.831-005.1-036.11-021.3-037:612.017.1.014

10.29254/2077-4214-2021-1-159-80-87