THE EFFECT OF THYROID HORMONES ON THE PARAMETERS OF STATIC PERIMETRY IN PATIENTS WITH PRIMARY OPEN-ANGLE GLAUCOMA WITH PRIMARY SUBCLINICAL HYPOTHYROIDISM
About the author:
Bezditko P. A., Babak Yu. A., Saveleva A. Yu.
CLINICAL AND EXPERIMENTAL MEDICINE
Type of article:
The relationship of primary open-ange glaucoma (POAG) with hypothyroidism is currently a topical issue in ophthalmic practice. A number of researchers have noted that there is some relationship between changes in the hormonal profile of the thyroid gland and the development of POAG. The data obtained allowed us to consider thyroid disease, in particular hypothyroidism, an independent risk factor for developing PCAG. Object and methods. There were 40 patients (40 eyes) under stage I-III POAG (on the perimeter of Humphrey) with primary subclinical hypothyroidism who studied hormonal markers of thyroid function (TSH, free T3, free T4). All patients underwent photometry, biomicroscopy, gonioscopy, tonometry, ophthalmoscopy, Humphrey perimetry. Humphrey (MD, PSD) perimetry was analyzed in these patients. Results. When examining the blood of patients with PCG with primary subclinical hypothyroidism, it was found that TSH levels ranged from 4.41 to 9.45 mIU/l and averaged 6.8 ± 0.4 mIU/l, free T3 from 5.9 to 12.8 pmol/l and averaged 8.4 ± 0.5 pmol/l, free T4 from 10.6 to 22.0 pmol/l, an average of 15.0 ± 0.9 pmol/l. Patients with PCG with primary subclinical hypothyroidism have a statistically significant dependence (p <0.05) of static perimetry on TSH, T3 free and T4 free in the blood, which confirms the dependence of the degenerative process on the thyroid hormone level. The TSH level in patients with MD <-12 dB was statistically significantly higher by 23%, in patients with MD> -12 dB higher by 57% compared with patients with MD <-6 dB; the level of T3-free in patients with MD <-12 dB below 57%, in patients with MD> -12 dB lower by 92% compared with patients with MD <-6 dB; the T4-free level in patients with MD <-12 dB is lower by 50%, in patients with MD> -12 dB lower by 110% compared with patients with MD <-6 dB. The TSH level in patients with PSD (5-7.5) is higher by 15%, in patients with PSD> 7.5 higher by 45% compared with patients with PSD <4.5; the T3-free level in patients with PSD (5-7.5) is lower by 63%, in patients with PSD> 7.5 lower by 115% compared with patients with PSD <4.5; the T4-free level in patients with PSD (5-7.5) is lower by 46%, in patients with PSD> 7.5 lower by 116% compared with patients with PSD <4.5.
thyroid hormones, primary open-angle glaucoma, subclinical hypothyroidism, perimeter
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Publication of the article:
«Bulletin of problems biology and medicine» Issue 2 (156), 2020 year, 78-82 pages, index UDK 617.7-007.681:617.754-072.7:616.441-008.64-078