HORMONAL CHARACTERISTICS OF DIABETES-ASSOCIATED OSTEOARTHRITIS

Orlenko V. L.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Joint damage in patients with diabetes mellitus (DM) is a common complication and is associated, first of all, with metabolic disorders due to an imbalance of various hormones and cytokines. The aim of our work was to study the level of insulin, leptin, osteocalcin, c-peptide, cortisol in patients with diabetes-associated osteoarthritis. Object and methods. The study involved 89 patients who were divided into groups by type of diabetes, the presence and severity of diabetic arthropathy. The content of insulin and leptin, osteocalcin, c-peptide, cortisol in blood serum was determined by enzyme immunoassay. Results. Among the patients examined, diabetic arthropathy was diagnosed in more than 70%. Patients with diabetic arthropathy significantly increased levels of insulin (with type 1 diabetes by 38.5%, with type 2 diabetes by 55.6%) and leptin (with type 1 diabetes by 43.8%, with type 2 diabetes by 53, 7%), the level of osteocalcin (only with type 1 diabetes by 53.9%), the c-peptide is reduced in patients with type 2 diabetes by 15%. There is a direct correlation between the severity of joint damage and the level of insulin and leptin. The severity of arthopathy in patients with type 2 diabetes is directly correlated with insulin resistance. In patients with diabetes-associated osteoarthritis with type 1 diabetes, the level of osteocalcin is increased, for the detection of arthropathy with type 1 diabetes with an increase in insulin levels increase by 3.8 times, with an increase in leptin by 1.3 times, in patients with type 2 diabetes – by 2.6 and 1.2 times, respectively. For this sample, it has been established that the development of arthropathy does not depend on gender and type of diabetes. Conclusions. In the pathogenesis of joint damage in patients with types 1 and 2 diabetes, hormonal dysregulation takes place. The most significant changes were identified for leptin and insulin in both types of diabetes. Thus, an increase in insulin and leptin levels can serve as a marker for the presence and progression of arthropathy in patients with diabetes mellitus. An increase in osteocalcin indicates a violation of remodeling of subchondral bone tissue in patients with type 1 diabetes.

diabetes mellitus, diabetic arthropathy, joints, chondrocytes, insulin, leptin, osteocalcin.

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«Bulletin of problems biology and medicine» Issue 2 (156), 2020 year, 138-143 pages, index UDK 616.611–002–036.12–08:577.125.8:577.15:616.839:[ 616. 1

10.29254/2077-4214-2020-2-156-138-143