DYNAMICS OF MORPHOMETRIC PARAMETERS OF RATS’ KIDNEYS OBTAINED FROM MOTHERS WITH EXPERIMENTAL METABOLIC SYNDROME

Korotchuk Y. V., Hrygorieva O. A.

MORPHOLOGY

Scentific article

Today much attention is paid to the study of the condition of the kidneys after exposure to factors in the prenatal period of development. The nature of maternal nutrition during pregnancy can be a trigger for the development of various pathological conditions in the offspring (cardiovascular disease, diabetes, overweight and obesity, including chronic kidney disease and renal failure. The aim of the study was to investigate the features of the dynamics of morphometric parameters of the renal corpuscles of the kidney of rats in the postnatal period, obtained from mothers with experimental metabolic syndrome. Object and methods. In order to understand the mechanisms of possible renal pathology in experimental metabolic syndrome was simulated in female white rats. The offspring were divided into 3 groups: control and two experimental (MS1 and MS2 ). The kidneys of offspring were investigated on the 1st, 7th, 14th, 21st, 30th, 60th, 90th and 120th day of postnatal life. Serial sections were stained with hematoxylin and eosin. Result and discussion. During the study, it was found that from the 1st to the 120th day of life in animals there was a gradual decrease in the relative area occupied by nephrons, with the most pronounced tendency to lag was observed in the offspring of animals receiving high-calorie food. There was also a decrease in the absolute number of renal corpuscles with minimal values at the end of the study period in both experimental groups, but in the group of animals with a standard diet us were less pronounced. In the group of MC1 rats at the end of the study period there was a significant predominance of the diameter of the vascular glomeruli in comparison with control animals and animals with a standard diet. Conclusions. The described changes reflect the dependence of the processes of formation of the cortical substance of the kidneys of the offspring on the nature of the mother’s diet and after the transition to self-feeding.

rat, kidney, metabolic syndrome, nephron, renal corpuscle.

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«Bulletin of problems biology and medicine» Issue 2 (156), 2020 year, 266-271 pages, index UDK 611.61.018.1-055.62]:616-008.9-092.9

10.29254/2077-4214-2020-2-156-266-271