CORRECTION OF MINERAL EXCHANGE INDICATORS IN CHILDREN WITH ENAMEL HYPOPLASIA LIVING IN ENVIRONMENTALLY POLLUTED AREAS

Labii Yu. A.

DENTISTRY

Scentific article

The article presents the results of biochemical studies of the indexes of mineral metabolism in biological fluids of children with systemic enamel hypoplasia and evaluation of efficiency after complex therapy during 3 years. The level of calcium and phosphorus were determined as the main macroelements of mineral exchange in the blood plasma and urine of the two study groups and the data were analyzed depending on the area of residence. Before using the treatment-and-prophylactic complex, the calcium level in the blood plasma in children of main group from all the study areas was not significantly higher than the control group (1.78 ± 0.06 and 1.66 ± 0.07 (mmol/l), respectively; p> 0,05). After treatment, the calcium content of the blood plasma of the main groul reached the limit and was (2.32 ± 0.06) mmol/l, which was more than its level before treatment by 1.30 times (p1 <0.001), as well as from the indicator of control group after treatment, which increased by only 0.01 mmol/l (p2 <0.001). After studying the dynamics of calcium levels in daily urine, it was found that before treatment, the content of this element in the main and control groups differed slightly between themselves (2.62 ± 0.14) and (2.37 ± 0.17) mmol/l, respectively (p> 0.05) and exceeded the standard rate (0-2.29 mmol/l). As a result of therapy, a significant decrease in the level of calcium in the daily urine in children of main group was observed to (1.81 ± 0.13) mmol/l (p1 <0.001), and the obtained indicator differed from the control group by 1.25 times (p2 <0.05). After 3 years of the treatment, the level of phosphorus in the blood plasma in children of main group decreased in1.26 times – up to (1.92 ± 0.06) mmol/l (p1 <0.001) and reached the limits of the standard (1.29-2, 26 mmol/l). In control group the level of phosphorus decreased by only 0.14 mmol/l and was higher than the main group by 1.17 times (p2 <0.001). Following the use of the proposed treatment-and-prophylactic complex in children of the main group from all the study areas, the level of calcium and phosphorus in blood plasma and urine increased, reaching the normal level. The most significant impact of the treatment was on the calcium and phosphorus indices of the residents of the Dolinsky district, which contaminated with oil products – the calcium levels in the blood plasma and phosphorus of the urine increased 1.33 and 1.31 times (p <0.01), respectively, and calcium levels of plasma blood and daily urine decreased 1.30 (p <0.01) and 1.41 (p <0.05) times, respectively.

children, hypoplasia, calcium, phosphorus, xenobiotics, treatment, prevention.

1. Bezvushko EV. Stomatolohichna zakhvoriuvanist ditei, yaki prozhyvaiut na riznykh za ekolohichnym stanom terytoriiakh, ta obgruntuvannia dyferentsiiovanoi profilaktyky urazhen tverdykh tkanyn zubiv [avtoreferat]. Kyiv: 2013. 36 s. [in Ukrainian].
2. Buchok RA, Bielikov OB. Poshyrenist nekarioznykh urazhen tverdykh tkanyn zubiv sered studentskoi molodi ta prychynno-naslidkovi zv’iazky yikh vynyknennia. Bukovynskyi medychnyi visnyk. 2012;16(4(64)):26-30. [in Ukrainian].
3. Kril IA, Rozhko MM. Poshyrenist systemnoi hipoplazii emali u shkoliariv m. Ivano-Frankivska. Halytskyi likarskyi visnyk. 2011;18(2):53-5. [in Ukrainian].
4. Liubarets SF, Antomonov MYu. Caries risk prognosis criteria in children with enamel hypoplasia of the permanent teeth, taking into account anthropogenic environmental factors. Environment & health. 2018;4:32-5.
5. Kovach IV, Dychko YeN, Bindiuhin OIu, Buniatian KhA. Potentsiini faktory ryzyku pry systemnii hipoplazii ta kariiesi zubiv na etapi odontohenezu. Medychni perspektyvy. 2013;18(1):33-7. [in Ukrainian].
6. Savychuk OV, Nemyrovych YuP, Holubieva IM. Stan mineralnoho obminu pry kariiesi v dytiachoho naselennia ekolohichno nespryiatlyvykh rehioniv. Sovremennaia stomatolohyia. 2010;4:78-80. [in Ukrainian].
7. Kuzniak NB, Hodovanets OI. Stomatolohichnyi status ditei, yaki meshkaiut na nitratno zabrudnenykh terytoriiakh. Novyny stomatolohii. 2010;2(63):83-4. [in Ukrainian].
8. Dovkillia Ivano-Frankivshchyny u 2010 rotsi: statystychnyi zbirnyk. Derzhavnyi komitet statystyky Ukrainy, Holovne upravlinnia statystyky v Ivano-Frankivskii oblasti za red. Zbroi LO. Ivano-Frankivsk: 2011. 151 s. [in Ukrainian].
9. Ostapko OI. Khimichnyi sklad emali ta stan tverdykh tkanyn postiinykh zubiv u ditei v riznykh za ekolohichnoiu sytuatsiieiu rehionakh Ukrainy. Novyny stomatolohii. 2007;4(53):38-42. [in Ukrainian].
10. Bezvushko EV. Morfolohichna kartyna rotovoi ridyny u ditei pry kariiesi zubiv z urakhuvanniam ekolohichnykh umov prozhyvannia. Novyny stomatolohii. 2010;2(63):80-2. [in Ukrainian].
11. Kril IA. Osoblyvosti likuvannia pliamystoi formy systemnoi hipoplazii emali zubiv u ditei na stadii nezavershenoi mineralizatsii emali. Visnyk problem biolohii i medytsyny. 2017;2:363-6. [in Ukrainian].
12. Hadzhula NH. Vyvchennia biodostupnosti likarskykh preparativ na osnovi mineralnykh komponentiv dlia profilaktyky kariiesu zubiv. Novyny stomatolohiyi. 2010;2(63):32-5. [in Ukrainian].
13. Zabolotna II. Rezultaty vykorystannia «Vitaftoru» u patsiientiv z nekarioznymy urazhenniamy zubiv. Ukrainskyi morfolohichnyi almanakh. 2010;8(2):60-1. [in Ukrainian].
14. Eremina NV, Romanovs’kaya LD, Posmetnaya TV, Viryasova NA, Nozdrina VD. Ispol’zovanie emal’-germetiziruyushchego likvida dlya profilaktiki i lecheniya kariesa i giperestezii zubov. Saratovskiy nauchno-meditsinskiy zhurnal. 2011;7(1):290-1. [in Russian].
15. Novykova NP, Bondarenko AN. Vlyianye sochetannoho prymenenyia preparatov kaltsyia y kholekaltsyferola na sostoianye tverdikh tkanei zubov u bolnikh hipotyreozom. Stomatolohyia dlia vsekh. 2011;1:8-12. [in Russian].
16. Savychuk OV, Nemyrovych YuP, Holubieva IM. Klinichna efektyvnist kompleksnoi profilaktyky kariiesu i hinhivitu u dytiachoho naselennia ekolohichno nespryiatlyvykh rehioniv. Novyny stomatolohii. 2010;3(64):82-4. [in Ukrainian].
17. Labii YuA. Shliakhy pidvyshchennia rezystentnosti emali zubiv u ditei, khvorykh na systemnu hipoplaziiu emali, shcho prozhyvaiut v raionakh iz riznym antropohennym zabrudnenniam [avtoreferat]. Ivano-Frankivsk: 2016. 15 s. [in Ukrainian].

«Bulletin of problems biology and medicine» Issue 2 (156), 2020 year, 358-362 pages, index UDK 616.314.13-007.23-07-085-053.2:502

10.29254/2077-4214-2020-2-156-358-362