INFLUENCE OF OVERWEIGHT AND OTHER RISK FACTORS OF ISCHEMIC HEART DISEASE ON THE DEVELOPMENT OF ACUTE MYOCARDIAL INFARCTION

Labinska O. Y., Kyyak Y. H., Halkevych M. P., Barnett O. Y.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Abstract. Background. Overweight is one of the leading risk factors of acute myocardial infarction (AMI). Due to AMI one of five patients dies within the first year. Purpose of the study was to investigate the influence of the prevalence of the main risk factors in ischemic heart disease (IHD) on the occurrence of AMI and to analyze clinical and laboratory parameters in the acute period of MI in patients with overweight andobesity. Object and methods: 158 patients with ST-elevation myocardial infarction (STEMI) age from 32 to 86 years were examined. All patients were divided into 3 groups: first group consisted of 52 people with normal body weight (body mass index (BMI) –18.5-24.9 kg/m2 ), second group – 51 patients with overweight(BMI25.0-29.9 kg/m2 ), third group – 55 people with obesity of I-III stages (BMI ≥30.0 kg/m2 ). Results. It was found that the most common classic risk factors were hypertension (88-95%), dyslipidemia (50-76%) and smoking (51-69%), regardless of BMI. Visceral obesity was detected in all 100% patients in third group(AMI and obesity I-III stages), in 82.35% patients with AMI and overweight and in 9.62% patients with AMI and normal body weight. In patients with AMI and obesity I-III stages significantly more often revealed the presence of dyslipidemia, type 2 diabetes, heredity and occupational hazards, compared to patients with AMI and normal body weight (p<0.05). Exceeding the target levels of cholesterol were in patients with overweight (52.94±6.99%) and obesity I-III stages(60.00±6.61%), LDL cholesterol – in each of the study groups, regardless of BMI. Conclusion.Hypertension, dyslipidemia and smoking were found to be the most common risk factors for IHD regardless of body mass index. In patients with acute myocardial infarction and obesityI-III stages dyslipidemia and type 2 diabetes were most common. Visceral obesity was found in all examined patients with obesityI-III stages,in overweight patients – 82.35% and in normal weight individuals – 9.62%

acute myocardial infarction, ischemic heart disease, risk factors, overweight, abdominal obesity.

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«Bulletin of problems biology and medicine» Issue 2 (160), 2021 year, 100-104 pages, index UDK 616.12-005.4+616-056.52)-038-06:616.127-005.8

10.29254/2077-4214-2021-2-160-100-104