PREVENTION AND TREATMENT OF PROSTHETIC STOMATITIS IN PATIENTS WITH DIABETES MELLITUS TYPE 2

Badalov R. M., Kovalenko G. A.

DENTISTRY

Scentific article

Abstract. The occurrence of prosthetic stomatitis is a multiethiopathogenetic process. Modern researches show the significantly higher prevalence of Candida albicans in patients with diabetes versus healthy subjects This is due to hypovitaminosis caused by a violation of carbohydrate metabolism. The presence of elevated blood glucose and saliva leads to exacerbation of fungal diseases, which, in turn, provokes a significant increase in microflora. The role of diabetes mellitus and the associated with it decrease of the tissue tolerance to elevated glucose levels may be a highly underestimated factor in the onset and chronicity of prosthetic stomatitis. The purpose of the present research to evaluate the effect of dental prostheses on the contamination of the oral mucosa with Candida fungi in patients with type 2 diabetes mellitus, as well as the effectiveness of prevention and treatment of prosthetic stomatitis. The research included 66 patients with type 2 diabetes. All examined patients received prostheses made of acrylic plastic materialof various configurations for the first time. The patients were divided into three groups: a control group, a group taking fluconazole orally in the dose of 200 mg once a day, and a group using applications under the bases of prostheses with 1% Clotrimazole cream 2 times a day. To assess microbial contamination, all subjects were examined before the start of the research, 7, 14 and 30 days after the installation of the prosthesis and the start of prophylaxis and treatment. The obtained data showed that Candida albicans fungi were isolated in 65.9% of the examined patients of all groups. Moreover, the level of contamination was significantly higher in patients using complete removable plate dentures. The use of 1% clotrimazole cream locally showed the highest efficiency in reducing the contamination of the oral mucosa with Candida fungi in comparison with other groups. This method can be recommended for use during the first two weeks after the installation of the prosthesis for the first time as a method of prevention and treatment of the fungal component of PS in patients with type 2 diabetes mellitus.

: prosthetic stomatitis, type 2 diabetes mellitus, microbiological assessment, efficiency, clotrimazole.

1. Salvi GE, Cosgarea R, Sculean A. Prevalence of Periimplant Diseases. Implant Dent. 2019;28(2):100-102. doi: 10.1097/ ID.0000000000000872.
2. Grizodub DV, Badalov RM. Otsenka mikrobnoi obsemenennosti polosti rta patsientov, stradayushchikh neperenosimostyu bazisnykh materialov s`emykh zubnykh protezov. Vistnik problem biologii imeditsiny. 2015;2.2(119):48-52. [in Russian].
3. Piemonte E, Lazos J, Belardinelli P, Secchi D, Brunotto M, Lanfranchi-Tizeira H. Oral cancer associated with chronic mechanical irritation of the oral mucosa. Med Oral Patol Oral Cir Bucal. 2018 Mar 1;23(2):151-160. doi: 10.4317/medoral.22017.
4. Bianchi CM, Bianchi HA, Tadano T, Paula CR, Hoffmann-Santos HD, Leite DPJr, et al. Factors related to oral candidiasis in elderly users and non-users of removable dental prostheses. Rev Inst Med Trop Sao Paulo. 2016;58:17. doi: 10.1590/S1678-9946201658017.
5. Soni AP, Astekar M, Metgud R, Ramesh G, Sharma A, Verma M. Candidal carriage in diabetic patients: a microbiological study. J Exp Ther Oncol. 2019 Jan;13(1):15-21.
6. Javed F, Al-Kheraif AA, Kellesarian SV, Vohra F, Romanos GE. Oral Candida carriage and species prevalence in denture stomatitis patients with and without diabetes. J Biol Regul Homeost Agents. 2017;31(2):343-346.
7. Zomorodian K, Kavoosi F, Pishdad GR, Mehriar P, Ebrahimi H, Bandegani A, et al. Prevalence of oral Candida colonization in patients with diabetes mellitus. J Mycol Med. 2016;26(2):103-110. doi: 10.1016/j.mycmed.2015. 12.008.
8. Matic Petrovic S, Radunovic M, Barac M, Kuzmanovic Pficer J, Pavlica D, Arsic Arsenijevic V, et al. Subgingival areas as potential reservoirs of different Candida spp in type 2 diabetes patients and healthy subjects. PLoS One. 2019 Jan 10;14(1):e0210527. doi: 10.1371/ journal.pone.0210527.
9. De la Torre-Luna R, Domínguez-Pérez RA, Guillén-Nepita AL, Ayala-Herrera JL, Martínez-Martínez RE, Romero-Ayala ME, et al. Prevalence of Candida albicans in primary endodontic infections associated with a higher frequency of apical periodontitis in type two diabetes mellitus patients. Eur J Clin Microbiol Infect Dis. 2020 Jan;39(1):131-138. doi: 10.1007/s10096-019-03702-z.
10. Jhugroo C, Divakar DD, Jhugroo P, Al-Amri SAS, Alahmari AD, Vijaykumar S, et al. Characterization of oral mucosa lesions and prevalence of yeasts in diabetic patients: A comparative study. Microb Pathog. 2019 Jan;126:363-367. doi: 10.1016/j.micpath.2018.11.028.
11. Millsop JW, Fazel N. Oral candidiasis. Clin Dermatol. 2016;34(4):487-494. doi: 10.1016/j.clindermatol.2016.02.022.
12. Polesello V, Segat L, Crovella S, Zupin L. Candida Infections and Human Defensins. Protein Pept Lett. 2017;24(8):747-756. doi: 10.2174/0929866 524666170807125245.

«Bulletin of problems biology and medicine» Issue 2 (160), 2021 year, 280-283 pages, index UDK 616.314-77266: 616.31-002-08(043.3)

10.29254/2077-4214-2021-2-160-280-283