THE ACUTE TOXICITY STUDY OF THE 3-METHYL-(1,3-DIMETHYL)-7-β-HYDROXY-γ-ARYLOXYPROPYLOXANTHINIOL8-TIOAXIC ACID

Bilai I. M., Tsys O. V., Ivanchenko D. G., Romanenko M. I.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

The problem of hyperlipidemia is one of the leading risk factors for cardiovascular diseases and the progression of their complications in the population. Despite the high hypolipidemic effect, the group of statins has a few disadvantages associated with both economic feasibility for patients and significant side effects. The creation of new highly effective and low-toxic drugs with a wide range of biological activity and their introduction into clinical practice is an important target of pharmacological and medical science. The purpose of this study is to investigate acute toxicity of synthesized 3-methyl-(1,3-dimethyl)-7-β-hydroxy-γaryloxypropyloxanthiniol-8-tioaxic acid derivatives in laboratory rats. Object and methods of the study. For the study of acute toxicity, 4 groups of animals were used, with 2 observations each with the additional use of one previous and subsequent dose. The compounds were administered to laboratory animals following the aseptic and antiseptic rules in the form of a fine aqueous suspension, which was stabilized with tween-80 at the rate of 0.2 ml tween-80 per 50 mg of the substance. Observations were made after 24 hours. In our studies, the acute toxicity of 20 compounds of 3-methyl-(1,3-dimethyl) -7-β-hydroxy-γ-aryloxypropylxanthinyl8-thioacetic acid derivatives was studied. The analysis of the studies was performed according to the classification of K.K. Sidorov. Results and their discussion. Analysis of the data obtained showed that the acute toxicity of new compounds obtained is in the range of 304–668 mg/kg. According to Sidorov’s classification, all synthesized 3-methyl (1,3-dimethyl)-7-β-hydroxy-γ-aryloxypropylxanthynyl-8-thioacetic acid derivatives turned out to be low toxic substances and belong to the III-IV toxicity classes (low toxic and moderately toxic substances) with intragastric administration. It has been established that among the studied substances, compound 6042 was the most toxic, and the least toxic – 6049. Conclusions.The study has found that synthesized 3-methyl-(1,3-dimethyl)-7-β-hydroxy-γ-aryloxypropylxanthynyl8-thioacetic acid derivatives turned out to be low toxic substances and belong to the III-IV toxicity classes. This experiment reflects the promise of research into this class of safe chemicals in further pharmacological experiments.

xanthines, acute toxicity, hyperlipidemia.

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«Bulletin of problems biology and medicine» Issue 3 (152), 2019 year, 77-79 pages, index UDK 547.857.4’298.71’53.024’491.4:615.015.35].074

10.29254/2077-4214-2019-3-152-77-79