ADIPOKINES LEVELS AND PRO-INFLAMMATORY ACTIVITY IN HYPERTENSIVE PATIENTS WITH DIFFERENT BODY WEIGHTS

Psarova V. G.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

The aim of the study was to determine the levels of adipokines and to evaluate pro-inflammatory activity in hypertensive patients with different body weights. We examined 300 patients with arterial hypertension (AH) from 45 to 55 years old who gave informed written consent to participate in the study and met the inclusion criteria. Group 1 consisted of 200 patients with AH and obesity I–II classes, group 2 – 50 patients with AH and normal body weight, group 3 – 50 patients with AH and overweight. The control group consisted of 30 practically healthy individuals, in whom AH and obesity were excluded on the basis of clinical and instrumental examination data. As a result of the study, it was found that in the presence of obesity, hypertensive patients had significantly higher levels of pro-inflammatory activity (interleukin-6 (IL-6) and C-reactive protein), as well as a more pronounced imbalance of adipokines (leptin and adiponectin) than hypertensive patients with normal weight and overweight. The degree of relatedness of indicators of pro-inflammatory activity, adipokines, anthropometric indices and severity of insulin resistance in hypertensive patients differed depending on body mass index (BMI): the most pronounced associations of these indicators were established in patients with obesity I-II classes; in normal body weight, no correlation was found; in overweight, correlations were established between leptin and adiponectin with HOMA index (HOMA-IR), and IL-6 – with BMI and HOMA-IR.

arterial hypertension, pro-inflammatory activity, adipokines, obesity, insulin resistance.

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«Bulletin of problems biology and medicine» Issue 3 (152), 2019 year, 181-185 pages, index UDK 616.12-008.331.1:613.25:616.43

10.29254/2077-4214-2019-3-152-181-185