Psarova V. G.


About the author:

Psarova V. G.



Type of article:

Scentific article


The aim of the study was to determine the levels of adipokines and to evaluate pro-inflammatory activity in hypertensive patients with different body weights. We examined 300 patients with arterial hypertension (AH) from 45 to 55 years old who gave informed written consent to participate in the study and met the inclusion criteria. Group 1 consisted of 200 patients with AH and obesity I–II classes, group 2 – 50 patients with AH and normal body weight, group 3 – 50 patients with AH and overweight. The control group consisted of 30 practically healthy individuals, in whom AH and obesity were excluded on the basis of clinical and instrumental examination data. As a result of the study, it was found that in the presence of obesity, hypertensive patients had significantly higher levels of pro-inflammatory activity (interleukin-6 (IL-6) and C-reactive protein), as well as a more pronounced imbalance of adipokines (leptin and adiponectin) than hypertensive patients with normal weight and overweight. The degree of relatedness of indicators of pro-inflammatory activity, adipokines, anthropometric indices and severity of insulin resistance in hypertensive patients differed depending on body mass index (BMI): the most pronounced associations of these indicators were established in patients with obesity I-II classes; in normal body weight, no correlation was found; in overweight, correlations were established between leptin and adiponectin with HOMA index (HOMA-IR), and IL-6 – with BMI and HOMA-IR.


arterial hypertension, pro-inflammatory activity, adipokines, obesity, insulin resistance.


  1. Bilovol OM, Shalimova AS, Kochuieva MM. Komorbidnist hipertonichnoi khvoroby i tsukrovoho diabetu 2 typu – aktualna problema suchasnoi medytsyny. Ukrainskyi terapevtychnyi journal. 2014;1:11-7. [in Ukrainian].
  2. Bratus VV, Talaeva TV, Shumakov VA. Ozhirenie, insulinorezistentnost, metabolicheskiy sindrom: fundamentalnyie i klinicheskie aspektyi. Kiev: Chetverta hvilya; 2009. 416 s. [in Russian].
  3. Dedov II, Melnichenko GA. Ozhirenie: etiologiya, patogenez, klinicheskie aspektyi. Moskva: Med. inform. аgentstvo; 2006. 456 s. [in Russian].
  4. Semple RK. How does insulin resistance arise, and how does it cause disease? Human genetic lessons. European Journal of Endocrinology. 2016;174:R209-R223.
  5. Whitehead JP, Richards AA, Hickman IJ. Adiponectin – a key adipokine in the metabolic syndrome. Diab, Obes, Metabol. 2006;8:264-80.
  6. Zhuravleva LV, Sokolnikova NV. Vklad ozhireniya v razvitie kardialnoy patologii u bolnyih saharnyim diabetom 2-go tipa. Liky Ukrainy. 2014;5- 6(181-182):10-5. [in Russian].
  7. Menezes AMB, Oliveira PD, Wehrmeister FC, Assunção MCF, Oliveira IO, Tovo-Rodrigues L, et al. Association of modifiable risk factors and IL-6, CRP, and adiponectin: Findings from the 1993 Birth Cohort, Southern Brazil. PLoS One. 2019 May 9;14(5):e0216202. DOI: 10.1371/journal. pone.0216202
  8. Singh RG, Nguyen NN, Cervantes A, Alarcon Ramos GC, Cho J, Petrov MS. Associations between intra-pancreatic fat deposition and circulating levels of cytokines. Cytokine. 2019 Aug;120:107-14. DOI: 10.1016/j.cyto.2019.04.011
  9. Townsend LK, Medak KD, Peppler WT, Meers GM, Rector RS, Leblanc PJ, et al. High Saturated Fat Diet-Induced Obesity Causes Hepatic Interleukin-6 Resistance via Endoplasmic Reticulum Stress. J Lipid Res. 2019 May 13. pii: jlr.M092510. DOI: 10.1194/jlr.M092510
  10. Provorotov VM, Drobyisheva ES, Bunina MN. Fenomen insulinorezistentnosti: mehanizmyi formirovaniya, vozmozhnosti diagnostiki i sposobyi korrektsii na sovremennom etape. Novyie Sankt-Peterburgskie vrachebnyie vedomosti. 2014;1:82-5. [in Russian].
  11. Kumar S, O’Rahylly S. Insulin Resistance. Insulin action and its disturbances in disease. Chichester; 2005. 599 p.
  12. Potapov VA, Chistiakov DA, Dubinina A. Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes. Rev Diabet Studies. 2008;5(1):28-37.
  13. Sheng T, Yang K. Adiponectin and its association with insulin resistance and type 2 diabetes. J Genet Genom. 2008;35:321-6.

Publication of the article:

«Bulletin of problems biology and medicine» Issue 3 (152), 2019 year, 181-185 pages, index UDK 616.12-008.331.1:613.25:616.43