QUANTITATIVE MORPHOLOGICAL ANALYSIS OF FEATURES OF REMODELING OF THE ARTERIAL BED OF THE COMMON BILE DUCT AT RESECTIONS OF DIFFERENT VOLUMES OF THE LIVER

Hnatjuk M. S., Monastyrskaya N. Ja., Tatarchuk L. V.

MORPHOLOGY

Scentific article

Removal of large volumes of liver, which is often performed in modern surgical clinics, can lead to postresection portal hypertension, which changes the hemodynamics of the hepatic portal vein, which leads to difficulty in venous drainage from the portal system and structural and functional changes in them. The arteries of the common bile duct of 45 laboratory white mature male rats, which were divided into 3 groups, were studied by a complex of morphological methods. 1 group had 15 intact animals (control), 2 – 15 rats after resection of the left lateral lobe – 31.5% of the liver parenchyma, 3 – 15 animals after removal of the right and left lateral lobes of the liver (58.1%). Resection of 58.1% of the liver parenchyma led to postresection portal hypertension, which was characterized by dilation and plethora of the portal and mesenteric veins, ascites, splenomegaly. The outer diameter of the small caliber arteries common bile duct was increased by 7.3% (p <0.001) compared with the control, the thickness of the media – by 34.3%, the thickness of the adventitia – by 58.2% (p <0.001), the lumen of the studied vessels and the Kernogan index decreased by 29.8% and 58.0%, respectively (p <0.001). Significant thickening of these arteries, a decrease in their lumen and Kernogen index indicated a significant decrease in the capacity of these vessels and the deterioration of blood supply to the studied organ. The relative volume of damaged endothelial cells increased by 14.8 times in postresection portal hypertension. Removal of 58.1% of the liver parenchyma leads to postresection portal hypertension and severe remodeling of the arteries of the common bile duct, which is characterized by thickening of their wall, narrowing of the lumen, decreased Kernogan index, increase in the relative volume of damaged endothelial cells, endothelial dysfunction, hypoxia, dystrophy, necrosis of tissues and cells cellular infiltration, sclerosis.

common bile duct, arteries, resection of the liver.

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«Bulletin of problems biology and medicine» Issue 3 (157), 2020 year, 222-224 pages, index UDK 616.143-018-06:616.367-005.2

10.29254/2077-4214-2020-3-157-222-224