THE PREVALENCE OF GASTROPATHIES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Derbak M. A., Zhovanik N. V., Lyakh O. I., Koval V. Yu., Lazur Ya. V.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

The article presents the results of examination of 479 patients with exacerbation of chronic obstructive pulmonary disease (COPD) during the period 2018 – September 2020. In 46% (218/47479) of patients, stage 2 COPD was diagnosed, in 13% (61/479) of persons – stage 1, 33% (155/479) – stage 3. There were fewer patients with stage 4 – 9% (45/479). By gender, men predominated (71% versus 29%). The various kinds of gastropathy were registered in 116 patients with COPD from 479, which is 25% from general number. The average age of patients with diagnosed gastropathies was 58±2.1 years. According to the GOLD strategy, the vast majority of patients (63%) with concomitant gastropathy (73 of 116) had many symptoms. Also, 60 people out of 116 (52%) being treated in a pulmonary hospital for COPD with concomitant gastropathy had many symptoms and stage 2 COPD. It was found that the most common gastropathy in patients with COPD is gastric dyspepsia, detected in 48% of patients, chronic gastritis was registered in 36%, GERD – 11% and gastric ulcer and duodenal ulcer – 4%. A positive H. pylori status was diagnosed in 27% of patients. Analyzing the structure of gastropathy, it was found that with an increase in the stage of COPD, the tendency to an increase in the frequency of chronic gastritis (from 25% in stage 1 to 50% in stage 4 of COPD) and a decrease in the frequency of patients with gastric dyspepsia (from 67% in stage 1 to 30% in 4 stages). The increase in the number of patients with concomitant chronic gastritis is probably due to the forced admission of patients with a long history of COPD inhaled or oral corticosteroids, a high incidence of Helicobacter pylori infection and tobacco smoking. Also, in 14% of patients, a combination of two nosologies was revealed, such as: GERD + gastric dyspepsia, GERD + chronic gastritis, GERD + gastric ulcer and duodenal ulcer. Accordingly, concomitant gastropathies are a common comorbid pathology in patients with COPD, since they are recorded in every fourth patient, with the maximum rate in patients with GOLD II (46%), among whom every fifth patient has a Helicobacter positive status.

prevalence, chronic obstructive pulmonary disease, gastropathies, concomitant pathology.

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«Bulletin of problems biology and medicine» Issue 4 (158), 2020 year, 118-121 pages, index UDK 616-039.1:616-34-002+616.24-002

10.29254/2077-4214-2020-4-158-118-121