PECULIARITIES OF HEMODYNAMICS OF URBAN RESIDENTS OF MIDDLE AGE WITH OBESITY, DEPENDING ON THE PRESENCE OF ARTERIAL HYPERTENSION

Iefimenko T. I., Misyura K. V.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

The article presents the results of a comprehensive study of hemodynamic features in 273 middleaged urban residents – representatives of the Ukrainian population – depending on their body weight and the presence of arterial hypertension. The study included persons who did not receive treatment in the past for hypertension and obesity. Body weight, waist and hip girth were measured in all examined subjects, body mass index and waist/hip girth ratio were determined, systolic and diastolic blood pressure was measured, mean and pulse blood pressure, total peripheral arterial resistance were calculated. Features of central hemodynamics were assessed by the method of integral body rheography according to the method of M.I. Tishchenko, taking into account the recommendations of I.S. Kolesnikov and co-authors. Indicators such as stroke volume (the amount of blood ejected during each heartbeat), cardiac output (the amount of blood ejected by the ventricles per minute), stroke index (ratio of cardiac output to body surface area), cardiac index – ratio of cardiac ejection to body surface area. The total peripheral vascular resistance was estimated, which was calculated as the ratio of mean arterial pressure to cardiac output. It was found that the development of obesity in this category is accompanied by a probable increase in the systolic function of the heart with the determination of the stroke volume of the heart and cardiac output, an increase in mean arterial pressure and total peripheral vascular resistance with a simultaneous decrease in the cardiac index and stroke index. In the presence of arterial hypertension, these changes are aggravated. A significant difference between obese and non-obese patients with arterial hypertension is an increase in the total peripheral vascular resistance. The leading role of visceral obesity in the development of arterial hypertension in the middle-aged urban population of Ukraine has been proven. The possibility of gluteofemoral fat depot to influence the development of hemodynamic disorders in obese persons has been registered. The prospect of further research in the direction of detailing the aspects of the pathogenesis of arterial hypertension and obesity in the population of Ukraine, which are the reasons for the increase in the total peripheral vascular resistance in persons with obesity and arterial hypertension, has been substantiated. The data revealed in the course of such work will make it possible to optimize preventive and therapeutic measures regarding this comorbid pathology in the adult population of Ukraine.

obesity, arterial hypertension, hemodynamics.

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«Bulletin of problems biology and medicine» Issue 4 (158), 2020 year, 126-131 pages, index UDK 616.056.52:616-036.22-08

10.29254/2077-4214-2020-4-158-126-131