COMPARATIVE ANALYSIS OF CLINICAL EFFICACY OSTEOPLASTIC MATERIALS FOR INCREASE THE ALVEOLAR BONE DURING SINUS – LIFTING OPERATION

Bambuliak A. V., Kuzniak N. B., Dmitrenko R. R., Tkachik S. V., Honcharenko V. A.

DENTISTRY

Scentific article

Every year, more than 2 million surgeries are performed in the world, during which there is a need to replace lost bone tissue. Such interventions are common in surgery, traumatology, oncology and in particular in dentistry. The problem of bone regeneration is one of the most pressing in modern surgical dentistry and maxillofacial surgery. Dental alveolar defects of the jaw bones are very common and are a serious problem in dental treatment and rehabilitation. Defects of the bone tissue of the maxillofacial area can occur as a result of various pathological processes, namely: traumatic tooth extraction, aggressive periodontitis, osteomyelitis of the jaws, tumors (benign, malignant and tumor-like), odontogenic and neodontogenic cysts, congenital and congenital. All these factors create extremely unfavorable conditions for the treatment of both primary and secondary adentia, especially if the method of treatment is dental implantation. Thus, the development of new implant materials for dentistry is a modern and not completely solved problem. The article presents a comparative analysis of the clinical effectiveness of osteoplastic materials, in particular compositions based on multipotent mesenchymal stromal cells of adipose tissue and platelet-enriched plasma, in filling bone defects during sinus lifting. Criteria for the effectiveness of treatment at the stage of early postoperative period in the subjects was to assess the severity of pain, collateral edema and the degree of hyperemia of the oral mucosa after surgery. The aim of the study. To determine the clinical effectiveness of osteoplastic materials to increase the volume of the alveolar bone of the jaws during operation of sinus lifting. Object and methods of research. The study was conducted on the basis of Bukovynian State Medical University, Chernivtsi, Ukraine. Sinus lifting operation was performed in 67 patients. At the same time, in 30 people the operation was performed using osteoplastic material “Kolapan – L” (subgroup 1A); in 37 people, surgery was accompanied by the use of osteoplastic combination of multipotent mesenchymal stromal cells of adipose tissue (MMSC – AT) + “Colapan – L” + platelet-enriched plasma PRP (subgroup 1B). Statistical processing of the obtained results was performed on a personal computer using the licensed programs “Microsoft Excel” and “Statistica”. Research results and their discussion. It was found that in patients of subgroups B, where “Kolapan – L” + MMSCAT + PRP was used, the absence of pain at the final stage of postoperative observation was noted by 89.31% of persons, which was 1,2 times p1 <0.05 more than in the operated subgroup A, p> 0,05. In the final postoperative stages, collateral edema was absent in 98.47% of operated subgroups B, which exceeded the number of persons in subgroup A, where the bone defect was augmented by “Colapan – L” 1,2 times, p1 <0.05. The absence of hyperemia of SOPR was determined in the final postoperative follow-up period in 92,37% of patients of subgroups B, which was 1,3 times more than the values in subgroup A p1 <0.05. Conclusions. Comparative analysis of the clinical effectiveness of osteoplastic materials to increase the volume of the alveolar bone of the jaws during sinus – lifting operation convincingly proved the advantage of using the combination “Kolapan – L” + MMSС – AT + PRP, which was confirmed by subjective and objective symptoms postoperative period.

sinus lifting, osteoplastic material, pain, collateral edema, hyperemia.

1. Amabile G, Meissner A. Induced pluripotent stem cells: current progress and potential for regenerative medicine. Trends in Molecular Medicine. 2014;15(2):59-68. PMID: 19162546. DOI: 10.1016/j.molmed.2008.12.003
2. Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 2015;105:1815-22. PMID: 15494428.
3. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 2015;284:143-7. PMID: 10102814. DOI: 10.1126/science.284.5411.143
4. Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation. 2014;6:230-47. PMID: 5654088
5. Vasilyev AV, Kuznetsova VS, Bukharova TB, Grigoriev TE, Zagoskin Y, Korolenkova MV, et al. Development prospects of curable osteoplastic materials in dentistry and maxillofacial surgery. Heliyon. 2020;6(8):e04686. Available from: https: // doi.org/ 10.1016 / j.heliyon. 2020
6. Kostenko Y, Mochalov I, Kaminsky R, Nakashidze G, Bun Y, Goncharuk-Khomyn M. Primeneniye sinteticheskogo osteoplasticheskogo materiala EASYGRAFT® pri subanatralnoy augmentatsii verkhney chelyusti. Meditsinskiye novosti Gruzii. 2018;285:32-6. [in Russiаn].
7. Kang DW, Yun PY, Choi YH, Kim YK. Sinus bone graft and simultaneous vertical ridge augmentation: case series study. Maxillofacial plastic and reconstructive surgery. 2019;41(1):36. Available from: https://doi.org/10.1186/s40902-019-0221
8. Juzikis E, Gaubys A, Rusilas H. Uses of maxillary sinus lateral wall bony window in an open window sinus lift procedure: literature review. Stomatologija. 2018;20(1):14-21.
9. Aghiad Yassin Alsabbagh, Mohammed Monzer Alsabbagh, Batol Darjazini Nahas, Salam Rajih. Comparison of three different methods of internal sinus lifting for elevation heights of 7 mm: an ex vivo study. International journal of implant dentistry. 2017;3(1):40. Available from: https://doi.org/10.1186/s40729-017-0103-5
10. Miron RJ, Zucchelli G, Pikos MA, Salama M, Lee S, Guillemette V, et al. Use of platelet-rich fibrin in regenerative dentistry: a systematic review. Clinical oral investigations. 2017;21(6):1913-27. Available from: https://doi.org/10.1007/s00784-017-2133-z

«Bulletin of problems biology and medicine» Issue 4 (158), 2020 year, 315-320 pages, index UDK 616-089.844:616.716]616-002

10.29254/2077-4214-2020-4-158-315-320