APPLICATION OF CRYOPRESERVED PLACENTA PREPARATIONS IN THE SMALL INTESTINE PATHOLOGIES IN RATS FOR THEIR FURTHER USE IN EXIGENT CONDITIONS

Shepitko K. V.

LITERATURE REVIEWS

Scentific article

The article is devoted to the problems of using the method of treating the small intestine pathologies by means of cryopreserved placenta products transplantation. The urgency of the problem is based on an analysis of the digestive diseases incidence among the population. A general analysis of the gastrointestinal diseases incidence among the population of Ukraine is presented. The total bulk of pharmacological drugs do not solve the primary task – restoration of the cellular composition in the damaged homologous organ. In addition to the development and use of synthesized pharmacological drugs for the gastrointestinal tract pathology correction, there is an ever growing focus on the cell and tissue transplantation and regeneration therapy, based on the use of allo- and xenogenic tissues and cells of embryo-fetoplacental complex. Due to the transplantation of placental and fetal cells and tissues, new possibilities have been used in the treatment of intractable and exigent conditions, particularly in cases of dystrophic processes, metabolic pathology, endocrine insufficiency, in combat injuries as a consequence of combat actions and in catastrophes. The purpose set for a group of UMSA researchers was to establish changes in the morphometric parameters of the duodenum, jejunum and ileum wall in rats with administration of cryopreserved placenta for its further use in medical emergency cases. The study of changes in the morphometric parameters of the small intestine wall’s different layers after administration of cryopreserved placenta is an urgent problem of modern experimental medicine, and can serve as a key for the proper treatment and prevention of bowel diseases and in exigent conditions caused by emergency situations.

diseases of the small intestine, exigent conditions, cryopreserved placenta, morphological parameters, duodenum, jejunum and ileum.

1. Vasilenko IV. Morfologicheskaya diagnostika bolezni Krona. Donetskiy natsionalnyy meditsinskiy universitet im. M. Gorkogo. Novosti meditsiny i farmatsii. 2011;358:35-7. [in Russian].
2. Grigoryeva GA, Meshalkina NYu. Bolezn Krona. Moskva: Meditsina; 2007. 184 s. [in Russian].
3. Efektyvne likuvannya zakhvoryuvan shlunkovo-kyshkovoho traktu v Poltavi, 9.10.2017 r. Dostupno: https://poltava.to/news/44585 [in Ukrainian].
4. Nakaz MOZ Ukrayiny № 438 vid 26.05.2010 «Pro zatverdzhennya protokoliv diahnostyky ta likuvannya zakhvoryuvan orhaniv travlennya u ditey» Dostupno: https://zakon.rada.gov.ua/rada/show/v0438282-10 [in Ukrainian].
5. Nakaz Ministerstva okhorony zdorovya Ukrayiny vid 31 zhovtnya 2013 roku № 943 «Unifikovanyy Klinichnyy Protokol Pervynnoyi, Vtorynnoyi (Spetsializovanoyi) Medychnoyi Dopomohy» Hastroezofahealna Reflyuksna Khvoroba. Dostupno: http://mtd.dec.gov.ua/images/ dodatki/2013_943GERX/2013_943_ykpmd_GERX.pdf [in Ukrainian].
6. Geboes K. Pathology of inflammatory bowel disease (IBD): variability with time and treatment. Colorectal Dis. 2001;3:2-12.
7. Bychkov MA, Yakhnytska MM. Poshyrenist hastroezofahealnoyi reflyuksnoyi khvoroby za danymy endoskopichnykh doslidzhen. Zdobutky klinichnoyi i eksperymentalʹnoyi medytsyny. 2017;2:38-42. [in Ukrainian].
8.  Adler G. Bolezn Krona i yazvennyy kolit. M.: GEOTAR-med; 2001. 528 s. [in Russian].
9. Belousova YeA. Yazvennyy kolit i bolezn Krona. Tver: Triada; 2002. 128 s. [in Russian].
10. Vorobyev GI, Khalif IL, redaktory. Nespetsificheskiye vospalitelnyye zabolevaniya kishechnika. M.: Miklosh; 2008. 400 s. [in Russian].
11. Khalif IL, Loranskaya ID. Vospalitelnyye zabolevaniya kishechnika (nespetsificheskiy yazvennyy kolit i bolezn Krona): klinika, diagnostika i lecheniye. M.: Miklosh; 2004. 88 s. [in Russian].
12. O’Connor MB, editor. Ulcerative colitis – epidemiology, pathogenesis and complications. InTech, Croatia; 2011. 280 p.
13. Lakatos PL. Is the epidemiology of inflammatory bowel disease changing in Eastern Europe? Scandinavian J. Gastroenterol. 2006;41(7):870-1.
14. Lakatos PL. Recent trends in the epidemiology of inflammatory bowel diseases: up or down? World J. Gastroenterol. 2006;12(38):6102-8.
15. Colombel JF, Vernier-Massouille G, Cortot A, Gower-Rousseau C, Salomez JL. Epidemiology and risk factors of inflammatory bowel diseases. Bull. Acad. Nat. Med. 2007;191(6):1105-18.
16. Loftus EV. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterol. 2004;126:1504-17.
17. Shanahan F, Bernstein CN. The evolving epidemiology of inflammatory bowel disease. Curr. Opin. Gastroenterol. 2009;25:301-5.
18. Kozlova NM. Medyko-sotsialne obgruntuvannya udoskonalennya modeli profilaktyky vyrazkovoyi khvoroby shlunku ta dvanadtsyatypaloyi kyshky [dysertatsiya]. Kyiv: NMAPO im. Shupyka; 2017. 26 s. [in Ukrainian].
19. Melnyk DV. Vyrazkova khvoroba dvanadtsyatypaloyi kyshky u shkolyariv: medychni ta epidemiolohichni osoblyvosti [dysertatsiya]. Kyiv: NMAPO im. Shupyka; 2019. 27 s. [in Ukrainian].
20. Zakharash MP, Lishchyshyna OM, Borota OV, Haponov VV, Danylyuk SV, Denysova MF, ta in. Khvoroba Krona. Adaptovana klinichna nastanova, zasnovana na dokazakh. Kyiv: 2015. 253 s. [in Ukrainian].
21. Malova NH, Komarova IV, Syrotenko LA, Brechka NM, Steblina OV, Kurylko YuS. Vplyv riznykh likarskykh form biopreparatu platsenty na funktsionalnu aktyvnist shchytovydnoyi zalozy shchuriv z eksperymentalnym hipotyreozom. Materialy naukovo-praktychnoyi konferentsiyi “Multydystsyplinarnyy pidkhid – klyuch do uspishnoyi terapevtychnoyi nauky ta praktyky” 18 zhovtnya 2012 roku. Kharkiv: 2012. 152 s. [in Ukrainian].
22. Skotarenko TA, Shepitko VI, Yeryomina NF. Morfolohichni zminy ta kharakterystyka morfometrychnykh pokaznykiv kapsuly nadnyrkovoyi zalozy pry korektsiyi eksperymentalnoho perytonitu vvedennyam kriokonservovanoyi platsenty. Aktualni problemy suchasnoyi medytsyny. 2017;4(60):82-7. [in Ukrainian].
23. Grishchenko VI, Goltsev AN. Transplantatsiya produktov embriofetoplatsentarnogo kompleksa. Ot ponimaniya mekhanizma deystviya k povysheniyu effektivnosti primeneniya. Zh. Problemy kriobiologii. 2002;1:54-84. [in Russian].
24. Hryshchenko VI, Prokopyuk OS, Shepitko VI, Strona VI, Yurchenko TM, Bobyryova LYe, Ryazantsev VV. Vykorystannya kriokonservovanoyi platsenty v likuvalniy praktytsi. Transplantolohiya. 2002;3(2):32-6. [in Ukrainian].
25. Bilash SM. Morfometrychna kharakterystyka vorotarnykh zaloz shlunka pry hostromu eksperymentalnomu hastryti ta pislya vvedennya preparatu “Plateks-platsentarnyy” na tli hostroho eksperymentalnoho hastrytu. Problemy kriobiolohiyi i kriomedytsyny. 2013;23(1):84-90. [in Ukrainian].
26. Selkina AB, Shepitko VI, Yeroshenko HA. Morfofunktsionalna kharakterystyka slyzovoyi obolonky yazyka v normi ta pislya transplantatsiyi kriokonservovanoyi platsenty. Problemy, dostyzhenyya i perspektivy razvitiya mediko-biolohycheskikh nauk i prakticheskoho zdravookhraneniya. 2010;146:70-3. [in Ukrainian].
27. Shepitko KV, Chaykovskyi YuB, Shepitko VI. Morfometrychna kharakterystyka stinky porozhnyoyi kyshky pry vvedenni kriokonservovanoyi platsenty na tli hostroho aseptychnoho zapalennya cherevnoyi porozhnyny u shchuriv. Visnyk morfolohiyi. 2014;1:184-8. [in Ukrainian].
28. Shepitko KV. Kharakterystyka morfometrychnykh parametriv stinky klubovoyi kyshky pry odnorazovomu vvedenni kriokonservovanoyi platsenty ta aseptychnomu zapalenni. Svit medytsyny ta biolohiyi. 2014;4(46):174-8. [in Ukrainian].
29. Shepitko KV. Morfometrychna kharakterystyka stinky dvanadtsyatypaloyi kyshky pry vvedenni kriokonservovanoyi platsenty u shchuriv. Svit medytsyny ta biolohiyi. 2013;4:117-20. [in Ukrainian].
30. Shepitko VI. Strukturno-funktsionalni pokaznyky kriokonservovanoyi platsenty i vplyv yiyi transplantatsiyi na morfofunktsionalnyi stan ryadu vnutrishnikh orhaniv [dysertatsiya]. In-t probl. kriobiolohiyi i kriomedytsyny. Kharkiv, 2004. 40 s. [in Ukrainian].
31. Shepitko VI, Katsay VV, Shepitko KV. Kharakterystyka strukturnykh elementiv selezinky pry transplantatsiyi kriokonservovanoyi platsenty. Svit medytsyny ta biolohiyi. 2011;2:76-8. [in Ukrainian].
32. Helsinska deklaratsiya Vsesvitnoyi medychnoyi asotsiatsiyi «Etychni pryntsypy medychnykh doslidzhen za uchastyu lyudyny u yakosti obyekta doslidzhennya» vid 01.06.1964 [Internet]. Dostupno: http:// zakon4.rada.gov.ua/laws/show/990_005 [in Ukrainian].
33. Shepitko VI, YurchenkoTM, Klymenko MO. Vplyv krioekstrakta platsenty na reaktsiyu tuchnykh klityn pry zapalenni. Visnyk problem biolohiyi i medytsyny. 2004;1:103-6. [in Ukrainian].

«Bulletin of problems biology and medicine» Issue 4 Part 2 (154), 2019 year, 56-61 pages, index UDK 616.340:615.368:618.36-026.656

10.29254/2077-4214-2019-4-2-154-56-61