LEVELS OF INTESTINAL INFLAMMATION MARKERS AS A DIAGNOSTIC CRITERION FOR FORMING A RISK GROUP FOR IDENTIFICATION OF SMALL INTESTINAL BACTERIAL OVERGROWTH IN ULCER COLIT
About the author:
Stepanov Yu. M., Psareva I. V., Tatarchuk O. M., Zygalo E. V., Petishko O. P.
CLINICAL AND EXPERIMENTAL MEDICINE
Type of article:
Aim. To determine the feasibility of using fecal markers of inflammation in patients with ulcerative colitis (UC) to form a risk group for the detection of excess small intestinal bacterial overgrowth (SIBO). Object and methods. A total of 52 patients with UC between the ages of 20 and 73 years were examined, among whom 26 were equally divided between women and men (50.0%). In all patients, SIBO was determined using a hydrogen breath test. Using enzyme immunoassay, the level of serum and feces α1-antitrypsin, the level of fecal calprotectin and fecal myeloperoxidase were determined. Results. SIBO was diagnosed in 63.5% of patients with UC. Moreover, with severe UC activity, patients with SIBO were 2.8 times higher than patients without SIBO (χ2 =8.69, p=0.0032). 1.5 times more often SIBO was detected with widespread colitis than with left-sided colitis and proctitis. Elevated levels of fecal markers of intestinal inflammation were combined with bacterial contamination of the small intestine. A direct correlation was established between the level of fecal myeloperoxidase and the detection rate of SIBO (r=0.74; p=0.04). The conclusion. The level of fecal myeloperoxidase of more than 4000 ng/g is a diagnostic criterion for the formation of a risk group for identifying SIBO in patients with UC (sensitivity 90.9%, specificity 84.0%).
ulcerative colitis, diagnosis, non-invasive markers of inflammation, small intestinal bacterial overgrowth.
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Publication of the article:
«Bulletin of problems biology and medicine» Issue 4 Part 2 (154), 2019 year, 204-207 pages, index UDK 616.34-002.44-008.87-078